Synthesis, Characterization, and Antibacterial and Anti-Inflammatory Activities of New Pyrimidine and Thiophene Derivatives

Table 3

In vitro anti-inflammatory activity of the synthesized compounds and standard drug (diclofenac sodium).

Compound number	Spectrophotometer + RBC	Spectrophotometer + RBC (% hemolysis)
3a	0.011 ± 0.0068	101.13 ± 0.0031
3b	0.013 ± 0.000516	102.1542 ± 0.021
3c	0.009 ± 0.000473	102.6048 ± 0.00402
3e	0.179 ± 0.01775	101.6216 ± 0.0005
4d	0.011 ± 0.0068	101.13 ± 0.0031
4e	0.098 ± 0.001227	102.686 ± 0.00211
5	0.101 ± 0.01862	101.9084 ± 0.0002
4a	0.017 ± 0.0075	101.908 ± 0.002404
4d	0.219 ± 0.0225	102.727 ± 0.0126
4c	0.032 ± 0.002	102.441 ± 0.01308
6a	0.146 ± 0.001366	102.523 ± 0.0187
6b	0.01 ± 0.00493	102.154 ± 0.00312
6c	0.046 ± 0.001789	102.236 ± 0.0107
7a	0.023 ± 0.000894	102.0723 ± 0.02135
7b	0.113 ± 0.001033	102.318 ± 0.0042
7c	0.029 ± 0.003225	102.113 ± 0.028
7d	0.066 ± 0.00324	102.2 ± 0.00301
7e	0.052 ± 0.0041	102.154 ± 0.0014
7f	0.06 ± 0.00319	101.908 ± 0.01405
Diclofenac sodium	0.132 ± 0.002251	102.851 ± 0.00076
Control	0.261 ± 0.002683	—
Blank	0.428 ± 0.002442	—