Synthesis, Characterization, X-Ray Crystallography, and Antileishmanial Activities of N-Linked and O-Linked Glycopyranosides

Table 1

Different coupling condition for amide synthesis.

Entry	Starting material		Reagents/conditions	Product (isolated yield%)
1	4a	HA	1.2 eq. DCC, cat. DMAP, CH2Cl2, r.t., 8 h	46
2	4a	HA	1 eq. EDC, cat. DMAP, CH2Cl2 r.t., 8 h	36
3	4a	HA	1.1 eq. EDC, cat. DMAP, CH2Cl2 r.t., 12 h	70
4	4a	HA	1.3 eq. EDC, cat. DMAP, CH2Cl2 r.t., 12 h	76
5	5a	HA	1.3 eq. EDC, cat. DMAP, CH2Cl2 r.t., 12 h	61
6	6a	HA	1.3 eq. EDC, cat. DMAP, CH2Cl2 r.t., 18 h	79