Synthesis, Characterization, X-Ray Crystallography, and Antileishmanial Activities of N-Linked and O-Linked Glycopyranosides

Table 3

% inhibition of compounds 5a–e and 7a–e against L. tropica leishmania.

Compound		Compound
5a	0.65 ± 0.01	7a	1.35 ± 0.04
5b	0.68 ± 0.09	7b	0.73 ± 0.12
5c	0.81 ± 0.16	7c	0.63 ± 0.18
5d	0.68 ± 0.27	7d	0.77 ± 0.08
5e	0.89 ± 0.11	7e	0.66 ± 0.18
	Standard drug IC50	(μg/mL ± SD)
	Amphotericin B	0.56 ± 0.20

inhibition activity: 100 = (nonsignificant; 0.95−0.80 = low; 0.79−0.70 = moderate; 0.69−0.60 = good; below 0.59−0.56 = significant activity).