Research Article
Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats
Table 2
Body weight and serum parameters of rats treated with different vitamin D metabolites.
| | | 1,25-(OH)2D3
(0.5 μg/kg body weight, administered intraperitoneally once, 12 h before sacrifice) | 25-OHD3
(6 μg/kg body weight, administered daily by oral gavage for 10 days) | Vitamin D3
(300 μg/kg body weight, administered intramuscularly, once 10 days before sacrifice) |
| | Body weight (g) | 254 ± 7.74
(241 ± 6.17) | 263 ± 4.62
(258 ± 10.2) | 246 ± 6.10
(247 ± 7.30) | | 25-OHD3(ng/ml) | 32.0 ± 4.02
(23.1 ± 3.88) | 87.9 ± 12.0
(25.6 ± 1.80) | 154.2 ± 14.2
(31.5 ± 4.73) | | 1,25-(OH)2D3 (pg/ml) | 237.6 ± 21.2
(37.4 ± 7.61) | 27.0 ± 3.32
(39.3 ± 7.37) | 27.1 ± 1.78
(30.9 ± 3.51) | | Total calcium (mM) | 2.85 ± 0.03
(2.68 ± 0.03) | 2.71 ± 0.02
(2.70 ± 0.03) | 2.64 ± 0.03
(2.69 ± 0.03) |
|
|
Mean ± SEM of respective control groups are given in brackets; asterisks indicate significant differences between treatment and control groups; , . |
