Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats

Table 3

RNA expression in the proximal jejunum of rats treated with different vitamin D metabolites normalized to GAPDH.

	1,25-(OH)2D3; (0.5 μg/kg body weight, administered intraperitoneally once, 12 h before sacrifice)	25-OHD3; (6 μg/kg body weight, administered daily by oral gavage for 10 days)	Vitamin D3; (300 μg/kg body weight, administered intramuscularly, once 10 days before sacrifice)
TRPV6	0.879 ± 0.142; (1 ± 0.08)	1.187 ± 0.267; (1 ± 0.148)	1.741 ± 0.938; (1 ± 0.161)
CaBP-D9K	4.773 ± 0.418; (1 ± 0.231)	0.469 ± 0.185; (1 ± 0.342)	0.437 ± 0.076; (1 ± 0.480)
PMCA1b	0.790 ± 0.082; (1 ± 0.0731)´	1.054 ± 0.156; (1 ± 0.061)	1.019 ± 0.286; (1 ± 0.283)
VDR	1.118 ± 0.107; (1 ± 0.254)	1.489 ± 0.362; (1 ± 0.148)	2.630 ± 1.682; (1 ± 0.113)
PXR	1.350 ± 0.165; (1 ± 0.150)	1.430 ± 0.271; (1 ± 0.122)	0.958 ± 0.087; (1 ± 0.080)
CYP3A9	0.756 ± 0.130; (1 ± 0.148)	1.219 ± 0.125; (1 ± 0.207)	1.056 ± 0.219; (1 ± 0.162)
CYP3A18	0.936 ± 0.108; (1 ± 0.169)	1.339 ± 0.162; (1 ± 0.091)	1.226 ± 0.203; (1 ± 0.095)
CYP3A62	0.907 ± 0.130; (1 ± 0.123)	1.163 ± 0.139; (1 ± 0.120)	1.049 ± 0.198; (1 ± 0.144)
MDR1a	1.154 ± 0.150; (1 ± 0.252)	1.723 ± 0.393; (1 ± 0.151)	1.174 ± 0.168; (1 ± 0.193)

Means ± SEM of respective control groups set to 1 are given in brackets; asterisks indicate significant differences between treatment and control groups; .