Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats

Table 4

RNA expression in the distal jejunum/ileum of rats treated with different vitamin D metabolites normalized to GAPDH.

	1,25-(OH)2D3; (0.5 μg/kg body weight, administered intraperitoneally once, 12 h before sacrifice)	25-OHD3; (6 μg/kg body weight, administered daily by oral gavage for 10 days)	Vitamin D3; (300 μg/kg body weight, administered intramuscularly, once 10 days before sacrifice)
VDR	0.976 ± 0.061; (1 ± 0.073)	0.732 ± 0.060; (1 ± 0.350)	1.027 ± 0.068; (1 ± 0.089)
PXR	0.991 ± 0.083; (1 ± 0.128)	1.163 ± 0.083; (1 ± 0.131)	1.178 ± 0.105; (1 ± 0.086)
CYP3A9	0.607 ± 0.088; (1 ± 0.055)	1.546 ± 0.222; (1 ± 0.185)	1.096 ± 0.162; (1 ± 0.170)
CYP3A18	0.763 ± 0.126; (1 ± 0.082)	1.061 ± 0.113; (1 ± 0.160)	1.381 ± 0.239; (1 ± 0.170)
CYP3A62	0.775 ± 0.082; (1 ± 0.064)	1.302 ± 0.105; (1 ± 0.146)	0.838 ± 0.074; (1 ± 0.138)
MDR1a	1.089 ± 0.071; (1 ± 0.074)	1.299 ± 0.191; (1 ± 0.159)	1.058 ± 0.160; (1 ± 0.242)

Mean ± SEM of respective control groups set to 1 are given in brackets; asterisks indicate significant differences between treatment and control groups; .