Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats

Table 5

RNA expression in the kidney of rats treated with different vitamin D metabolites normalized to GAPDH.

	1,25-(OH)2D3; (0.5 μg/kg body weight, administered intraperitoneally once, 12 h before sacrifice)	25-OHD3; (6 μg/kg body weight, administered daily by oral gavage for 10 days)	Vitamin D3; (300 μg/kg body weight, administered intramuscularly, once 10 days before sacrifice)
VDR	1.488 ± 0.135; (1 ± 0.066)	0.833 ± 0.076; (1 ± 0.072)	0.775 ± 0.075; (1 ± 0.089)
PXR	0.804 ± 0.063; (1 ± 0.048)	0.905 ± 0.082; (1 ± 0.075)	0.729 ± 0.092; (1 ± 0.068)
CYP24A1	32.28 ± 5.041; (1 ± 0.276)	1.292 ± 0.464; (1 ± 0.464)	1.958 ± 0.530; (1 ± 0.202)
CYP27B1	0.187 ± 0.026; (1 ± 0.152)	1.034 ± 0.264; (1 ± 0.368)	0.429 ± 0.104; (1 ± 0.558)
MDR1a	1.240 ± 0.078; (1 ± 0.082)	1.295 ± 0.142; (1 ± 0.147)	0.653 ± 0.065; (1 ± 0.345)
MDR1b	0.915 ± 0.147; (1 ± 0.253)	1.227 ± 0.366; (1 ± 0.205)	1.193 ± 0.291; (1 ± 0.157)

Means ± SEM of respective control groups set to 1 are given in brackets; asterisks indicate significant differences between treatment and control groups; , .