Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats

Table 6

RNA expression in the liver of rats treated with different vitamin D metabolites normalized to β-actin.

	1,25-(OH)2D3; (0.5 μg/kg body weight, administered intraperitoneally once, 12 h before sacrifice)	25-OHD3; (6 μg/kg body weight, administered daily by oral gavage for 10 days)	Vitamin D3; (300 μg/kg body weight, administered intramuscularly, once 10 days before sacrifice)
VDR	1.398 ± 0.198; (1 ± 0.092)	1.014 ± 0.204; (1 ± 0.184)	1.000 ± 0.190; (1 ± 0.198)
PXR	0.666 ± 0.096; (1 ± 0.120)	0.889 ± 0.137; (1 ± 0.211)	0.950 ± 0.094; (1 ± 0.161)
CYP3A9	1.157 ± 0.235; (1 ± 0.196)	0.983 ± 0.064; (1 ± 0.122)	1.223 ± 0.119; (1 ± 0.104)
CYP3A18	0.661 ± 0.094; (1 ± 0.097)	0.789 ± 0.071; (1 ± 0.118)	1.115 ± 0.175; (1 ± 0.074)
CYP3A62	1.087 ± 0.183; (1 ± 0.084)	0.875 ± 0.089; (1 ± 0.135)	1.166 ± 0.119; (1 ± 0.062)
MDR1a	0.828 ± 0.099; (1 ± 0.139)	0.946 ± 0.107; (1 ± 0.102)	1.218 ± 0.149; (1 ± 0.158)
MDR1b	1.398 ± 0.254; (1 ± 0.222)	0.813 ± 0.097; (1 ± 0.230)	1.437 ± 0.256; (1 ± 0.152)

Means ± SEM of respective control groups set to 1 are given in brackets; asterisks indicate significant differences between treatment and control groups; .