Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats

Table 7

RNA expression in the brain of rats treated with different vitamin D metabolites normalized to GAPDH.

	1,25-(OH)2D3; (0.5 μg/kg body weight, administered intraperitoneally once, 12 h before sacrifice)	25-OHD3; (6 μg/kg body weight, administered daily by oral gavage for 10 days)	Vitamin D3; (300 μg/kg body weight, administered intramuscularly, once 10 days before sacrifice)
VDR	0.853 ± 0.051; (1 ± 0.193)	0.983 ± 0.054; (1 ± 0.111)	0.950 ± 0.073; (1 ± 0.106)
PXR	2.128 ± 0.992^#; (1 ± 0.216)	1.045 ± 0.045; (1 ± 0.115)	1.710 ± 0.656; (1 ± 0.168)
BCRP	0.703 ± 0.072; (1 ± 0.071)	1.145 ± 0.107; (1 ± 0.125)	1.371 ± 0.183; (1 ± 0.095)
MDR1a	0.719 ± 0.052; (1 ± 0.065)	0.971 ± 0.066; (1 ± 0.070)	1.045 ± 0.084; (1 ± 0.068)
MDR1b	0.975 ± 0.109; (1 ± 0.209)	1.027 ± 0.162; (1 ± 0.171)	1.187 ± 0.170; (1 ± 0.137)

Means ± SEM of respective control groups set to 1 are given in brackets; asterisks indicate significant differences between treatment and control groups; ^#P = 0.053, , and .