Journal of Chemistry / 2019 / Article / Sch 1

Research Article

Synthesis and Cytotoxic Activity against K562 and MCF7 Cell Lines of Some N-(5-Arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazoline-2-yl)thio)acetamide Compounds

Scheme 1

Synthetic route for the preparation of the target compounds. Ar = 4-(CH3)2NC6H4 (6a), 4-BrC6H4 (6b), 4-ClC6H4 (6c), 4-FC6H4 (6d), 2-FC6H4 (6e), 4-CH3OC6H4 (6f), 4-HOC6H4 (6g), 3-HOC6H4 (6h), C6H5 (6i), 4-O2NC6H4 (6j), 3-O2NC6H4(6k), 2-O2NC6H4 (6l), 3, 4-(OCH2O)C6H3 (6m), 3-CH3O-4-HOC6H3 (6n), and C6H5CH = CH (6o).