Journal of Chemistry / 2019 / Article / Tab 2

Research Article

Synthesis and Cytotoxic Activity against K562 and MCF7 Cell Lines of Some N-(5-Arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazoline-2-yl)thio)acetamide Compounds

Table 2

IC50 (μg/mL) on two cancer cell lines of the compounds.

NoCompoundsIC50 (μg/mL)
K562MCF7

1Doxorubicin1.8 ± 0.12.4 ± 0.1
25>10058.1 ± 3.8
36a>10098.0 ± 0.4
46b>100>100
56c>100>100
66d>100>100
76e>100>100
86f>10065.4 ± 7.6
96g>100>100
106h>100>100
116i>100>100
126j93.8 ± 0.7>100
136k>100>100
146l>10087.4 ± 2.2
156m>100>100
166n>100>100
176o>100>100

The experiments were done in triplicate. The presented data show mean ± SD. The values were calculated by using GraphPad Prism 5 software.