Synthesis and Cytotoxic Activity against K562 and MCF7 Cell Lines of Some N-(5-Arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazoline-2-yl)thio)acetamide Compounds

Table 2

IC₅₀ (μg/mL) on two cancer cell lines of the compounds.

No	Compounds	IC50 (μg/mL)
		K562	MCF7
1	Doxorubicin	1.8 ± 0.1	2.4 ± 0.1
2	5	>100	58.1 ± 3.8
3	6a	>100	98.0 ± 0.4
4	6b	>100	>100
5	6c	>100	>100
6	6d	>100	>100
7	6e	>100	>100
8	6f	>100	65.4 ± 7.6
9	6g	>100	>100
10	6h	>100	>100
11	6i	>100	>100
12	6j	93.8 ± 0.7	>100
13	6k	>100	>100
14	6l	>100	87.4 ± 2.2
15	6m	>100	>100
16	6n	>100	>100
17	6o	>100	>100

The experiments were done in triplicate. The presented data show mean ± SD. The values were calculated by using GraphPad Prism 5 software.