Parallelism of Chemicostructural Properties between Filgrastim Originator and Three of Its Biosimilar Drugs

Figure 1

Overlay of the four chromatograms obtained by qualitative analysis of Granulokine® (GRA_black), Tevagrastim® (TEV_blue), Nivestim™ (NIV_magenta), and Zarzio® (ZAR_green), showing the presence of the filgrastim peak (retention time 17.567, 17.505, 17.572, and 17.466 min, respectively).