Parallelism of Chemicostructural Properties between Filgrastim Originator and Three of Its Biosimilar Drugs

Figure 3

Chromatograms of Granulokine® (GRA_black), Nivestim™ (NIV_blue), Zarzio® (ZAR_green), and Tevagrastim® (TEV_magenta): compared (a); overlapped (b). By comparing chromatograms (a), it is possible to highlight the similar profile of all digested drugs performed in the nonreducing condition. By overlapping the same chromatograms (b), it is possible to better esteem the small discrepancy about the intensity due to experimental conditions.

(a)

(b)