Parallelism of Chemicostructural Properties between Filgrastim Originator and Three of Its Biosimilar Drugs

Figure 5

MALDI-TOF/TOF-MS spectra of filgrastim originator: (a) Granulokine® (GRA) and its biosimilars; (b) Tevagrastim® (TEV); (c) Nivestim™ (NIV); (d) Zarzio® (ZAR), after both digestion in the nonreducing condition and Zip-Tip C18 purification.

(a)

(b)

(c)

(d)