Computational Molecular Modeling of Pin1 Inhibition Activity of Quinazoline, Benzophenone, and Pyrimidine Derivatives

Scheme 3

Pyrimidine derivatives as potent Pin1 inhibitor core structure (a) for molecules 27–37, (b) for molecules 38–43, (c) for molecules 44–46, (d) for molecules 47 and 48, (e) Molecule 49, and (f) Molecule 52.