Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Compound</td><td class="align_center"><i>R</i><sub>m0</sub> ± SD</td><td class="align_center">Log <i>P</i></td><td class="align_center">Log <i>P</i><sub>calc</sub> [<a href="/journals/jchem/2019/3407091/#B12" target="_blank">12</a>]</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Ketoprofen</td><td class="align_center">1.8491 ± 0.1226</td><td class="align_center">2.66</td><td class="align_center">2.86</td></tr><tr><td class="align_left">Naproxen</td><td class="align_center">1.8623 ± 0.0736</td><td class="align_center">2.69</td><td class="align_center">2.79</td></tr><tr><td class="align_left">Ibuprofen</td><td class="align_center">2.3091 ± 0.1944</td><td class="align_center">3.47</td><td class="align_center">3.48</td></tr><tr><td class="align_left">Flurbiprofen</td><td class="align_center">2.5076 ± 0.1392</td><td class="align_center">3.82</td><td class="align_center">3.77</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>The <i>R</i><sub>m0</sub>, Log <i>P</i>, and Log <i>P</i><sub>calc</sub> values of the investigated compounds.</div>

Journal of Chemistry

tab3

Table 3

Table 3: Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography 