Synthesis, Antibacterial Evaluation, and QSAR of Caffeic Acid Derivatives

Scheme 1

Synthesis of the caffeic acid derivatives: (a) ROH, H₂SO₄, reflux; (b) Et₃N, RX, acetone, reflux; (c) DMF, K₂CO₃, RX, room temperature; (d) ROH, THF, TPP, DIAD, 0°C to room temperature.