PI3K Inhibitors of Novel Hydrazide Analogues Linked 2-Pyridinyl Quinazolone Scaffold as Anticancer Agents

Table 2

IC₅₀ of highly cytotoxic active derivatives against human cancer cell lines.

Compounds	IC50 (mean ± SEM) (μM)
	HePG-2
9	60.29 ± 1.06
12	104.94 ± 2.46
16a	126.40 ± 1.83
Doxorubicin	69.60 ± 1.50

IC₅₀: compound concentration wanted to restrain the cell viability by 50%.