PI3K Inhibitors of Novel Hydrazide Analogues Linked 2-Pyridinyl Quinazolone Scaffold as Anticancer Agents

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Compound</td><td class="align_center">PI3K</td></tr><tr class="thead"><td class="align_center">IC<sub>50</sub> (mean ± SEM) (<i>µ</i>M)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">9</td><td class="align_center">31.92 ± 3.26</td></tr><tr><td class="align_left">12</td><td class="align_center">112.34 ± 11.14</td></tr><tr><td class="align_left">16a</td><td class="align_center">74.48 ± 2.91</td></tr><tr><td class="align_left">LY294002</td><td class="align_center">57.30 ± 2.02</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Inhibitory activities of compounds <b>9</b>, <b>12</b>, and <b>16a</b> against PI3K.</div>

Journal of Chemistry

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Table 3

Table 3: PI3K Inhibitors of Novel Hydrazide Analogues Linked 2-Pyridinyl Quinazolone Scaffold as Anticancer Agents 