Research Article
New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia
Table 3
Bioactivities of tested compounds 1–5.
| | Compounds | MIC (µg·mL−1) | Cytotoxicity | | S. aureus | B. licheniformis | E. xiangfangensis | E. fergusonii | P. aeruginosa | HTB-176, IC50 |
| | 1 | >25 | >25 | 9.3 ± 10.2 | >25 | 7.4 ± 2.4 | Inactive | | 2 | >25 | >25 | >25 | 6.3 ± 7.8 | 5.7 ± 5.9 | 22 ± 2.94 | | 3 | 1.4 ± 2.4 | >25 | >25 | 2.5 ± 1.7 | 0.13 ± 0.4 | 10 ± 3.92 | | 4 | >25 | >25 | >25 | >25 | 12.5 ± 14.2 | 2 ± 7.6 | | 5 | >25 | >25 | >25 | >25 | >25 | Inactive | | Amikacin | 0.523 | 0.523 | 0.523 | 0.523 | 0.523 | — | | Kahalalide F | — | — | — | — | — | 4.3 ± 0.25 |
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MIC>25 μg·mL −1; IC 50 in μM. |
