Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains

Figure 11

MDK₉₉ was determined by measuring the time to kill 99% of the population, in P. aeruginosa clinical strains with concentration 1x the MIC of ciprofloxacin (red histogram), P. aeruginosa wild-type clinical strains (green histogram, WT) and LasR mutant clinical strains (blue histogram, LasR mut) with 1x the MIC ET37. value < 0.01, obtained by Studentʼs t-test. Data are presented as the mean ± SD.