Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains

Figure 2

Evaluation of biofilm mass after LasR antagonists (#1, 2, 3, 4) treatment on (a) P. aeruginosa PAO1 strain and after treatment with number 3 and number 4 compounds on (b) wild-type and (c) LasR mutant clinical strains, using crystal violet assay. (d) Evaluation of biofilm mass after treatment with number 3 and number 4 compounds, using Syto9 assay in LasR wild-type (upper line) and mutant clinical (lower line) strains. Studentʼs t-test.

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