Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains

Figure 5

Schematic synthesis of ET37 and ET39 compounds. Conditions: (a) WSC/HOBt, DMF, 0°C, o.n., Y = 88%. (b) NaOH 2N, EtOH, r.t. 4 h, Y = quant. (c) WSC/HOBt, cyclopentylamine, DMF, 0°C, 12 h, Y = 71%. (d) WSC/HOBt, L-homoserine, NMO, DMF, 12°h, Y = 63%.