Synthesis of Phenols via Metal-Free Hydroxylation of Aryl Boronic Acids with Aqueous TBHP

Table 3

Substrate scope for the direct hydroxylation of aryl boronic acids^a.

Entry	Substrate	Product	Yield (%)^b,c
1			92
2			90
3			93
4			87
5			92
6			90
7			85
8			89
9			60
10			95
11			47
12			nd^d
13			10^e

^aReaction conditions: aryl boronic acid (1 mmol), aqueous TBHP (2 mmol), TBHP (2 mmol), KO^tBu (1 mmol), and H₂O (1 mL), 50°C; ^bisolated yield; ^cproducts were characterized by MP, FTIR, and ¹H- and ¹³C-NMR; ^dthe desired product was not isolated; ^eCharacterized by FTIR.