Synthesis, Characterization and Antibacterial Activity of Schiff Base, 4-Chloro-2-{(E)-[(4-Fluorophenyl)imino]methyl}phenol Metal (II) Complexes

Table 1

Antibacterial screening data for the Schiff base ligand and its metal (II) complexes at concentrations of 10, 20, 30, and 40 µg/mL.

Zone of inhibition in against bacterial strains
Sample	Conc. (µg/mL)	Gram-positive		Gram-negative
		E. coli	P. aeruginosa	B. subtilis	S. typhi
L	10	7.3 ± 0.5	8.4 ± 0.5	7.7 ± 0.9	8.4 ± 0.5
	20	7.5 ± 0.5	8.7 ± 0.5	7.9 ± 0.9	8.6 ± 0.5
	30	7.7 ± 0.5	8.9 ± 0.8	8.5 ± 0.8	8.8 ± 0.5
	40	8.0 ± 0.5	10.0 ± 0.8	9.0 ± 0.8	8.9 ± 0.5
[Mn(L)2(H2O)2]	10	8.1 ± 0.5	10.7 ± 0.8	9.7 ± 0.5	9.3 ± 0.5
	20	8.6 ± 0.5	11.0 ± 0.8	10.3 ± 0.8	9.6 ± 0.5
	30	8.9 ± 0.5	12.±0.5	10.9 ± 0.5	9.8 ± 0.5
	40	9.7 ± 0.5	14.7 ± 0.5	11.7 ± 0.5	10.2 ± 0.5
[Co(L)2(H2O)2]	10	9.0 ± 0.9	9.7 ± 1.2	8.3 ± 0.5	9.4 ± 1.2
	20	9.2 ± 0.8	10.7 ± 1.4	8.9 ± 0.9	9.7 ± 0.5
	30	9.8 ± 0.5	11.3 ± 1.2	9.3 ± 0.5	11.0 ± 0.8
	40	10.0 ± 0.8	12.0 ± 0.8	10.2 ± 0.5	11.7 ± 0.5
[Ni(L)2(H2O)2]	10	9.5 ± 0.8	11.3 ± 0.5	9.7 ± 0.5	8.6 ± 0.5
	20	10.0 ± 0.8	11.8 ± 0.5	9.9 ± 0.5	8.8 ± 0.5
	30	10.4 ± 0.8	12.4 ± 0.5	10.8 ± 0.5	9.0 ± 0.8
	40	11.3 ± 0.9	12.7 ± 1.2	11.0 ± 0.8	9.3 ± 0.8
[Cu(L)2(H2O)2]	10	8.1 ± 0.8	10.3 ± 1.2	8.6 ± 0.5	8.7 ± 0.5
	20	8.3 ± 0.5	10.6 ± 1.2	9.3 ± 0.5	8.9 ± 0.5
	30	8.6 ± 0.5	10.9 ± 1.2	10.0 ± 0.8	9.3 ± 0.5
	40	8.9 ± 0.9	11.7 ± 1.2	10.7 ± 0.5	9.6 ± 0.5
[Zn(L)2(H2O)2]	10	7.6 ± 0.9	10.0 ± 0.5	8.4 ± 0.9	10.1 ± 0.9
	20	7.8 ± 0.5	10.4 ± 1.4	8.9 ± 0.9	10.3 ± 0.9
	30	8.1 ± 0.5	10.9 ± 1.2	9.7 ± 0.5	11.0 ± 1.2
	40	8.3 ± 0.5	11.4 ± 0.8	9.9 ± 0.9	11.6 ± 1.4
Amoxyclav (AMC)		8.0 ± 0.0	—	—	—
Nalidixic acid (NA)		12.0 ± 1.0	20.0 ± 2.0	13.0 ± 1.0	30.5 ± 0.5
Gentamicin (GEN)		9.0 ± 0.0	14.0 ± 0.0	9.5 ± 0.5	10.5 ± 1.5

L = Schiff base ligand, 4-chloro-2-{(E)-[(4-fluorophenyl)imino]methyl}phenol (C₁₃H₉ClFNO)  = average of three replicates ± SD.