Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides

Table 1

The cytotoxicity of target compounds 5a–5o against SKBr3, MDA-MB-231, and MCF-7 cancer cell lines.

Compounds	Substituents	IC50 (μmol/L)
	R	SKBr3	MDA-MB-231	MCF-7
5a		47.89 ± 0.44	45.55 ± 0.56	34.34 ± 0.50
5b		43.80 ± 0.12	35.55 ± 0.22	37.34 ± 0.16
5c		33.82 ± 0.33	35.35 ± 0.19	35.87 ± 0.13
5d		43.22 ± 0.26	33.78 ± 0.22	34.32 ± 1.23
5e		23.12 ± 0.16	23.78 ± 0.27	27.54 ± 0.18
5f		23.45 ± 0.26	27.78 ± 0.33	24.50 ± 0.23
5g		23.10 ± 0.26	20.33 ± 0.21	27.51 ± 0.33
5h		17.10 ± 0.26	16.33 ± 0.11	13.51 ± 0.13
5i		15.16 ± 0.11	17.39 ± 0.12	13.51 ± 0.14
5j		17.10 ± 0.20	17.55 ± 0.23	14.52 ± 0.32
5k		9.16 ± 0.11	10.34 ± 0.36	8.50 ± 0.26
5l		16.10 ± 0.11	15.39 ± 0.46	12.51 ± 0.33
5m		19.20 ± 0.11	18.30 ± 0.15	16.33 ± 0.12
5n		16.11 ± 0.12	15.33 ± 0.26	16.51 ± 0.21
5o		14.18 ± 0.22	16.30 ± 0.34	13.56 ± 0.11
Tamoxifen		7.54 ± 0.16	10.68 ± 0.23	9.05 ± 0.22