Research Article
A Simple RP-HPLC Method to Simultaneously Assay the Contents of Lamivudine, Tenofovir, and Nevirapine in Fixed Dose Combined Oral Antiviral Medicines
Table 1
Chemical data on drug substances considered in the study.
| | Drug substance | Code | Chemical structure | Mol wt. (g/mol) | cLog P | pKa | Solubility |
| | Lamivudine | 3TC |
C8H11N3O3S | 229.3 | −1.46 | 13.90 | Soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96%) |
| | Tenofovir disoproxil fumarate | TDF |
C23H34N5O14P | 635.5 | 2.65 | 3.75 | Slightly soluble in water, soluble in methanol, very slightly soluble in dichloromethane |
| | Nevirapine | NVP |
C15H14N4O | 266.3 | 2.65 | 2.8 | Practically insoluble in water, sparingly soluble or slightly soluble in methylene chloride, slightly soluble in methanol |
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