Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation

Table 1

Physical data of compounds (4a-h and 5).

Compounds 4a-h and 5	R 1	R 2	R 3	R 4	Molecular formula	Molecular weight g mol^−1	Yield (%) method		M.P. (°C)
							I	II
a	H	H	H	H	C20H13N3O3S2	407.47	70	65	218–220
b	H	H	CH3	H	C21H15N3O3S2	421.49	86	80	223–225
c	H	H	H	NO2	C20H12N4O5S2	452.46	83	71	215–217
d	H	H	OCH3	H	C21H15N3O4S2	437.49	84	76	219–221
e	Cl	H	Cl	H	C20H11N3O3S2Cl2	476.36	80	66	235–237
f	Cl	H	H	H	C20H12N3O3S2Cl	441.91	83	70	234–236
g	H	H	H	OCH3	C21H15N3O4S2	437.49	84	78	225–227
h	H	H	Br	H	C20H12BrN3O3S2	486.36	80	76	241–243
5	—	—	—	—	C13H9N3O3S2	319.36	85	—	212–215