Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation

Table 2

Antimicrobial activity data of compounds from 4a-h.

Compound	Concentration (μg/ml)	Zone of inhibition (in mm)
		Gram-positive		Gram-negative		Fungal strain
		B. subtilis	S. aureus	P. aeruginosa	E. coli	C. abicans	A. niger
4a	100	24	25	23	26	24	21
b	100	24	18	21	23	21	19
c	100	25	29	24	28	24	21
d	100	21	24	23	25	23	20
e	100	25	29	26	29	23	21
f	100	26	28	25	28	25	22
g	100	21	24	24	26	21	19
h	100	25	29	24	27	23	21
Ciprofloxcin	50	26	28	24	28	—	—
Miconazole	50	—	—	—	—	25	25