Research Article
Synthesis of Novel Diclofenac Hydrazones: Molecular Docking, Anti-Inflammatory, Analgesic, and Ulcerogenic Activity
Table 2
Analgesic effect of compounds on hot plate reaction time in mice.
| Treatment (n = 6) | Dose (mg/kg) | Predrug | Reaction time (seconds) postdrug | 30 min | 60 min | 120 min | Mean ± SE | % change | Mean ± SE | % change | Mean ± SE | % change |
| Diclofenac | 10 | 5.00 ± 0.36 | 7.33 ± 0.0.33 | 46.66 | 11.50 ± 0.60 | 130 | 14.16 ± 0.30 | 183.33 | 2 | 15.47 | 4.33 ± 0.33 | 5.00 ± 0.36 | 15.38 | 5.50 ± 0.42 | 26.92 | 6.50 ± 0.42 | 50 | 3 | 15.47 | 4.16 ± 0.30 | 7.66 ± 0.33 | 84 | 10.66 ± 0.71 | 156 | 11.33 ± 0.66 | 172 | 7 | 15.47 | 4.16 ± 0.30 | 6.50 ± 0.42 | 56 | 5.33 ± 0.33 | 28 | 5.83 ± 0.30 | 40 | 8 | 16 | 4.16 ± 0.30 | 7.33 ± 0.33 | 76 | 10.33 ± 0.42 | 148 | 12.66 ± 0.33 | 204 | 11 | 16 | 4.83 ± 0.30 | 5.66 ± 0.42 | 17.24 | 5.33 ± 0.33 | 10.34 | 6.33 ± 0.33 | 31.03 | 13 | 14.5 | 5.16 ± 0.30 | 8.66 ± 0.46 | 67.74 | 10.83 ± 0.74 | 109.67 | 12.16 ± 0.60 | 135.48 |
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All values represent mean ± SEM. ; ; , followed by Student’s t-test. |