Synthesis of Novel Diclofenac Hydrazones: Molecular Docking, Anti-Inflammatory, Analgesic, and Ulcerogenic Activity

Table 2

Analgesic effect of compounds on hot plate reaction time in mice.

Treatment (n = 6)	Dose (mg/kg)	Predrug	Reaction time (seconds) postdrug
			30 min		60 min		120 min
			Mean ± SE	% change	Mean ± SE	% change	Mean ± SE	% change
Diclofenac	10	5.00 ± 0.36	7.33 ± 0.0.33	46.66	11.50 ± 0.60	130	14.16 ± 0.30	183.33
2	15.47	4.33 ± 0.33	5.00 ± 0.36	15.38	5.50 ± 0.42	26.92	6.50 ± 0.42	50
3	15.47	4.16 ± 0.30	7.66 ± 0.33	84	10.66 ± 0.71	156	11.33 ± 0.66	172
7	15.47	4.16 ± 0.30	6.50 ± 0.42	56	5.33 ± 0.33	28	5.83 ± 0.30	40
8	16	4.16 ± 0.30	7.33 ± 0.33	76	10.33 ± 0.42	148	12.66 ± 0.33	204
11	16	4.83 ± 0.30	5.66 ± 0.42	17.24	5.33 ± 0.33	10.34	6.33 ± 0.33	31.03
13	14.5	5.16 ± 0.30	8.66 ± 0.46	67.74	10.83 ± 0.74	109.67	12.16 ± 0.60	135.48

All values represent mean ± SEM. ; ; , followed by Student’s t-test.