Research Article
Synthesis of Novel Diclofenac Hydrazones: Molecular Docking, Anti-Inflammatory, Analgesic, and Ulcerogenic Activity
Table 3
Analgesic activity of compounds by acetic acid-induced.
| Treatments (n = 6) | Dose (mg/kg) | Number of writhing in 20 min. | % inhibition |
| Control (acetic acid) | | 34.16 ± 1.41 | | Diclofenac | 10 | 8.00 ± 0.57 | 76.58 | 2 | 15.47 | 24.83 ± 0.79 | 27.31 | 3 | 15.47 | 8.16 ± 0.83 | 76.09 | 7 | 15.47 | 14.83 ± 1.01 | 56.85 | 8 | 16 | 8.16 ± 0.47 | 76.09 | 11 | 16 | 10.33 ± 0.80 | 69.75 | 13 | 14.5 | 8.03 ± 0.42 | 76.60 |
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All values represent mean ± SEM. , followed by Student’s t-test. |