Synthesis of Novel Diclofenac Hydrazones: Molecular Docking, Anti-Inflammatory, Analgesic, and Ulcerogenic Activity

Table 6

Docking energies of the compounds with COX-1 and COX-2 proteins.

Compd.	Energies; Cox-1 (kJ/mol)	Energies; Cox-2 (kJ/mol)	Compd.	Energies; Cox-1 (kJ/mol)	Energies; Cox-2 (kJ/mol)
1	−8.8	−10	8	−9.4	−9.4
2	−8.4	−10	9	−8.3	−9.6
3	−8.7	−9.9	10	−8.3	−9.6
4	−9.2	−9.8	11	−8.4	−9.5
5	−8.5	−9.7	12	−9.1	−9.9
6	−8.5	−10.4	13	−9.8	−9.9
7	−8.2	−9.6	14	−8.8	−10
			Diclofenac	−6.6	−8.1