3D-QSAR Study of the Chalcone Derivatives as Anticancer Agents

Table 3

Possible CoMSIA results.

Descriptors	Q^2	R^2	N	F	SEE
Steric (S)	0.637	0.943	3	55.27	0.068
Electrostatic (E)	0.543	0.901	3	56.98	0.090
Hydrophobic (H)	0.508	0.932	3	45.35	0.075
H-bond donor (D)	0.406	0.650	3	06.18	0.170
H-bond acceptor (A)	0.745	0.872	3	22.66	0.103
EA	0.724	0.898	3	29.29	0.092
ED	0.430	0.834	3	16.75	0.117
EH	0.487	0.907	3	32.64	0.087
ES	0.484	0.931	3	44.98	0.075
SA	0.833	0.919	3	37.57	0.082
SD	0.568	0.832	3	16.53	0.118
SH	0.584	0.958	3	75.26	0.059
AH	0.751	0.911	3	33.95	0.086
AD	0.637	0.832	3	16.86	0.117
DH	0.547	0.819	3	15.07	0.122
SHE	0.550	0.925	3	41.04	0.079
SED	0.501	0.881	3	24.65	0.099
SEA	0.779	0.916	3	36.19	0.083
SHA	0.806	0.934	3	47.29	0.074
SHD	0.601	0.868	3	21.85	0.104
SAD	0.645	0.873	3	22.88	0.102
EAD	0.608	0.879	3	24.11	0.100
EAH	0.742	0.913	3	34.86	0.080
AHD	0.679	0.872	3	22.73	0.103
EDH	0.533	0.871	3	22.45	0.103
SEHD	0.574	0.897	3	28.93	0.092
SEHA	0.773	0.928	3	42.72	0.077
SHDA	0.727	0.897	3	28.95	0.092
EHDA	0.653	0.886	3	25.93	0.079
SEAD	0.661	0.885	3	25.69	0.097
SEHDA	0.697	0.903	3	31.00	0.089