Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents

Table 4

ANOVA results of the quadratic multiple regression model for flavone di-C-glycosides.

Source	Sum of squares	df	Mean square	F value	value prob. > F	Remarks
Model	59.93	9	6.66	68.09	<0.0001	Significant
X 1: liquid-solid ratio	0.99	1	0.99	10.15	0.0154	Significant
X 2: water content	3.75	1	3.75	38.35	0.0004	Significant
X 3: extraction time	2.23	1	2.23	22.76	0.002	Significant
X 1 X 2	0.16	1	0.16	1.62	0.2441
X 1 X 3	2.64	1	2.64	27.05	0.0013	Significant
X 2 X 3	3.7	1	3.7	37.86	0.0005	Significant
	19.86	1	19.86	203.04	<0.0001	Significant
	16.8	1	16.8	171.78	<0.0001	Significant
	5.31	1	5.31	54.29	0.0002	Significant
Residual	0.68	7	0.098
Lack of fit	0.32	3	0.11	1.18	0.4215	Not significant
Pure error	0.36	4	0.091
Cor. total	60.61	16
R-squared	0.9887
Adj. R-squared	0.9742
Pred. R-squared	0.9057
Adeq. precision	22.075