Research Article
Synthesis, Radiolabeling, and Biological Evaluation of 68Ga-Mucin1 and Its Folate Hybrid Peptide Conjugates for the Diagnosis of Ovarian Cancer
Table 1
Biodistribution of 68Ga-NODAGA-MUC1-FA hybrid and 68Ga-NODAGA-MUC1 peptide conjugates in normal Balb/c mice.
| | 68Ga-labeled MUC1-folate hybrid peptide | 68Ga-labeled MUC1 peptide | 15 min | 60 min | 120 min | 15 min | 60 min | 120 min |
| Blood | 3.78 ± 1.16 | 1.34 ± 0.13 | 0.82 ± 0.31 | 3.43 ± 0.66 | 0.79 ± 0.40 | 0.18 ± 0.07 | Liver | 1.32 ± 1.10 | 1.58 ± 1.32 | 0.92 ± 0.12 | 2.22 ± 0.34 | 1.06 ± 0.30 | 0.46 ± 0.14 | Lung | 1.34 ± 1.02 | 1.94 ± 1.19 | 1.38 ± 0.34 | 2.61 ± 0.59 | 0.98 ± 0.18 | 0.23 ± 0.08 | Kidney | 13.00 ± 1.21 | 5.34 ± 1.99 | 1.19 ± 0.40 | 16.16 ± 0.75 | 8.07 ± 0.36 | 5.56 ± 0.74 | Intestine | 0.76 ± 0.39 | 1.39 ± 0.66 | 0.66 ± 0.34 | 2.07 ± 0.52 | 1.24 ± 0.69 | 0.52 ± 0.06 | Heart | 1.35 ± 0.83 | 0.64 ± 0.54 | 0.54 ± 0.33 | 2.58 ± 0.38 | 0.63 ± 0.23 | 0.14 ± 0.04 | Muscle | 0.82 ± 0.43 | 0.31 ± 0.59 | 0.59 ± 0.46 | 1.73 ± 0.27 | 0.94 ± 0.66 | 0.15 ± 0.05 | Bone | 0.78 ± 0.34 | 0.25 ± 0.52 | 0.52 ± 0.12 | 0.70 ± 0.26 | 0.99 ± 0.57 | 0.42 ± 0.15 | Spleen | 1.47 ± 0.94 | 1.13 ± 0.49 | 0.66 ± 0.07 | 1.75 ± 0.38 | 1.31 ± 0.12 | 0.67 ± 0.21 |
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The values are average of % injected dose/gram ± SD for n = 4.
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