Synthesis, Radiolabeling, and Biological Evaluation of ⁶⁸Ga-Mucin1 and Its Folate Hybrid Peptide Conjugates for the Diagnosis of Ovarian Cancer

Table 1

Biodistribution of ⁶⁸Ga-NODAGA-MUC1-FA hybrid and ⁶⁸Ga-NODAGA-MUC1 peptide conjugates in normal Balb/c mice.

	^68Ga-labeled MUC1-folate hybrid peptide			^68Ga-labeled MUC1 peptide
	15 min	60 min	120 min	15 min	60 min	120 min
Blood	3.78 ± 1.16	1.34 ± 0.13	0.82 ± 0.31	3.43 ± 0.66	0.79 ± 0.40	0.18 ± 0.07
Liver	1.32 ± 1.10	1.58 ± 1.32	0.92 ± 0.12	2.22 ± 0.34	1.06 ± 0.30	0.46 ± 0.14
Lung	1.34 ± 1.02	1.94 ± 1.19	1.38 ± 0.34	2.61 ± 0.59	0.98 ± 0.18	0.23 ± 0.08
Kidney	13.00 ± 1.21	5.34 ± 1.99	1.19 ± 0.40	16.16 ± 0.75	8.07 ± 0.36	5.56 ± 0.74
Intestine	0.76 ± 0.39	1.39 ± 0.66	0.66 ± 0.34	2.07 ± 0.52	1.24 ± 0.69	0.52 ± 0.06
Heart	1.35 ± 0.83	0.64 ± 0.54	0.54 ± 0.33	2.58 ± 0.38	0.63 ± 0.23	0.14 ± 0.04
Muscle	0.82 ± 0.43	0.31 ± 0.59	0.59 ± 0.46	1.73 ± 0.27	0.94 ± 0.66	0.15 ± 0.05
Bone	0.78 ± 0.34	0.25 ± 0.52	0.52 ± 0.12	0.70 ± 0.26	0.99 ± 0.57	0.42 ± 0.15
Spleen	1.47 ± 0.94	1.13 ± 0.49	0.66 ± 0.07	1.75 ± 0.38	1.31 ± 0.12	0.67 ± 0.21

The values are average of % injected dose/gram ± SD for n = 4.