Synthesis, Radiolabeling, and Biological Evaluation of ⁶⁸Ga-Mucin1 and Its Folate Hybrid Peptide Conjugates for the Diagnosis of Ovarian Cancer

Table 2

Biodistribution of ⁶⁸Ga-NODAGA-MUC1-FA hybrid and ⁶⁸Ga-NODAGA-MUC1 peptide conjugates in KB tumor-bearing nude mice.

	^68Ga-labeled MUC1-folate hybrid peptide			^68Ga-labeled MUC1 peptide
	15 min	60 min	120 min	15 min	60 min	120 min
Blood	6.24 ± 1.16	1.52 ± 0.27	0.47 ± 0.13	4.63 ± 1.29	1.03 ± 0.91	0.18 ± 0.01
Liver	1.95 ± 0.09	1.72 ± 0.20	1.18 ± 0.20	3.10 ± 0.47	2.53 ± 0.94	0.55 ± 0.01
Lung	2.52 ± 0.85	0.91 ± 0.11	0.76 ± 0.21	3.21 ± 0.77	1.11 ± 1.15	0.34 ± 0.09
Kidney	18.40 ± 5.55	7.58 ± 0.69	6.55 ± 0.43	16.76 ± 1.85	7.58 ± 5.58	4.98 ± 0.44
Intestine	1.58 ± 1.07	1.99 ± 0.43	1.50 ± 0.55	1.34 ± 0.45	1.44 ± 1.82	0.85 ± 0.99
Heart	1.30 ± 0.62	0.51 ± 0.16	0.56 ± 0.22	2.26 ± 0.02	0.53 ± 0.42	0.53 ± 0.05
Muscle	1.25 ± 0.15	0.76 ± 0.45	0.36 ± 0.07	1.19 ± 0.10	0.39 ± 0.24	0.25 ± 0.07
Bone	1.50 ± 0.35	0.37 ± 0.14	0.17 ± 0.05	1.53 ± 0.38	1.72 ± 0.15	0.45 ± 0.15
Spleen	1.32 ± 0.33	0.76 ± 0.05	0.53 ± 0.16	1.37 ± 0.41	1.16 ± 0.66	1.12 ± 0.47
Tumor	12.92 ± 4.38	4.85 ± 0.17	0.89 ± 0.03	2.75 ± 0.23	0.71 ± 0.52	0.35 ± 0.01

The values are average of % injected dose/gram ± SD for n = 4.