Journal of Chemistry

Journal of Chemistry / 2021 / Article

Review Article | Open Access

Volume 2021 |Article ID 2575598 | https://doi.org/10.1155/2021/2575598

Bikash Adhikari, Babita Aryal, Bibek Raj Bhattarai, "A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.", Journal of Chemistry, vol. 2021, Article ID 2575598, 11 pages, 2021. https://doi.org/10.1155/2021/2575598

A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.

Academic Editor: Xinyong Liu
Received03 Oct 2021
Accepted20 Nov 2021
Published07 Dec 2021

Abstract

With the emergence of epidemics, pandemics, and infectious diseases, several research activities have been carried out on natural products to tackle them. As there are structural diversities in natural products, researchers are focused on exploring them for treatment and/or management of various infections and/or diseases. Acacia catechu (L.f.) Willd. belonging to the order Fabales and family Fabaceae shows a wide range of pharmacological functions in the management of diseases in humankind. This review was carried out to gather and provide information about the chemical constituents and pharmacological activities of A. catechu through the literature survey of scientific articles. On preliminary assessments, A. catechu is demonstrated as a significant wellspring of bioactive compounds with a wide range of biological and pharmaceutical applications such as antidiabetic, antioxidant, antimicrobial, anticancer, antidiarrheal, anti-inflammatory, antiviral, hepatoprotective, immunomodulatory, and so on. Although the metabolites from the plant are reported with diverse pharmacological applications, there is little information in regards to toxicity and clinical trials on bioactive compounds of this plant. Further research on diverse bioactive compounds from the plant is required to develop them as a successful potent drug.

1. Introduction

With the beginning of civilization, humans have been messed with various infectious diseases and many lives have battled in adapting to them. Various preventive and/or treatment approaches have been established to counter them. Among them, natural products are a rich source or tool of research for the management of diseases for the welfare of humankind [13]. Isolation and identification of bioactive compounds or drugs from natural products’ pool have a long history [4], and research on them has acquired tremendous profound due to their bioactive functions against different infections, diverse nature and structural complexity, cost-effectiveness, and least side effects [5, 6]. More than 50% of all drugs witnessed in modern medicines are through natural products and their derivatives [7]. In other words, approximately 35% of the global market of medicines have been run or originated through natural products [8]. With the growing research on medicinal plants, A. catechu is also one of the important bioactive plants. This study explores on chemical constituents and pharmacological functions of A. catechu through the literature-based analysis. The scientific information about A. catechu was gathered from articles by searching them in Google Scholar, PubMed, Elsevier, ScienceDirect, Scopus, Springer, Wiley online library, and Web of Science.

2. Botanical Characteristics and Traditional Uses

A. catechu is a deciduous thorny tree of up to 15–17 m height native to central and east Africa, Southern Asia, Bhutan, China, India, Pakistan, Myanmar, and Nepal [9]. It is a medium-sized tree with dark greyish-brown to dark brown barks, brown branches which are slender, puberulous when young, but glabrescent later, straight and grayish-brown stem, petiolate, bipinnately compound and alternate leaves, oblong and glabrous leaflets, white to pale yellow flowers in 5–10 cm-long axillary spikes with a campanulate 1–1.5 mm-long calyx, 2.5–3 mm long corolla, and pod-based fruits with ovoid seeds [10, 11].

The taxonomic position of A. catechu (L.f.) Willd. is given as follows:Kingdom: PlantaeDivision: TracheophytaClass: MagnoliopsidaOrder: FabalesFamily: FabaceaeGenus: AcaciaSpecies: catechuVernacular name: Khayar or Khair

A. catechu has been used traditionally against different diseases, especially gastrointestinal and stomach-related ailments, leprosy, and skin diseases [12, 13]. In Ayurveda, it is used for mouth and mucous problems, cough, diarrhea, and skin diseases [14]. An Ayurvedic skin tonic called “Khadirarishta” is prepared from A. catechu. Additionally, many synonyms such as “Balapatra,” “Bahushalya,” “Dantadhavana,” “Gayatri,” “Kanthi,” “Kusthaghna,” “Raktasara,” “Vakrakanta,” and “Yadnyiya” are used in Ayurveda [15]. In Sanskrit, A. catechu is named “Khadira” and “Raktasaar.” In traditional Chinese medicine, its heartwood extract is called “Ercha” and is used in cough and dysentery, as well as topically for skin ulceration and lesions [16, 17]. The extracts of bark and heartwood of this plant are used for treating broken horns of cattle in veterinary folk medicine [13, 17]. The heartwood decoction is used as a disinfectant in ulcers, skin eruptions, and burns cases and also in case of toothache and body ache [14, 18, 19]. It is also used while bathing to get rid of pains. Pregnant women take it to warm their bodies. Leaves of the plant have been used as fodder, particularly for sheep, goats, cows, and buffalos [20]. In simple words, it has been shown with varied roles in the management of diseases such as dysentery, colitis, gastric problems, asthma, cough, renal problems, leprosy, sore throat, gingivitis, and dental and oral infections [17, 19, 21]. Gum exudates from Acacia species have been widely used as a demulcent, emulsifiers, adhesives, and stabilizers in the food, textile, cosmetic, and soft-drink industries [16, 22].

3. Chemical Composition and Pharmacological Applications

A. catechu contains phytochemicals with diverse pharmaceutical and biological activities (Figure 1) [23]. Several factors such as climatic conditions, harvesting time, storage conditions, development stages, variability, and genetic factors are responsible for diversities in their secondary metabolites [24]. On phytochemicals screening of methanol extract of A. catechu heartwood; tannins, terpenoids, triterpenoids, alkaloids, ascorbic acid, and carbohydrates were tested positive [25], while leaf extract showed the presence of resins and saponins additionally [10]. In another study, methanol extract of plant bark showed the presence of alkaloids, carbohydrates, flavonoids, tannins, and steroids [26].

A. catechu heartwood comprises 66.9% of catechins and 23.1% of epicatechins which are responsible for the bioactivities [27, 28]. Caprylic acid methyl ester (1), lauric acid methyl ester (2), 2-ethyl-3-methyl-1-butene (3), and myristic acid methyl ester (4) (Figure 1) were identified from A. catechu leaf extract on gas chromatography–mass spectrometry (GC/MS) analysis [29]. Catechin (5), epicatechin or acacatechin (6), 4-hydroxybenzoic acid (7), afzelechin (8), epiafzelechin (8), mesquitol (10), ophioglonin (11), aromadendrin (12), kaempferol (13), baicalin (14), baicalein (15), and quercetin (16) (Figure 2) were isolated from A. catechu [3033] and are responsible for pharmacological applications. In addition to these compounds, quercetin 3-methyl ether (17), caryatin (18), and ellagic acid (19) were isolated and identified from ethanolic extract of A. catechu leaves through spectroscopic techniques and compared with literature values [34]. Similarly, phenolic compounds such as 5-hydroxy-2-[2-(4-hydroxyphenyl)acetyl]-3-methoxylbenzoic acid (20), (2S,3S)-3,7,8,3′,4′-pentahydroxyflavane (21), rhamnetin (22), 4-hydroxyphenyl ethanol (23), 3,3′,5,5′,7-pentahydroxyflavane (24), and fisetinidol (25) (Figure 2) were isolated from aqueous extract of A. catechu [35]. Through ultrahigh performance liquid chromatography (UHPLC) analysis, A. catechu extract was found to contain ellagic acid (19), rutin (26), quercetin (16), gallic acid (27), catechin (5), chlorogenic acid (28), umbelliferone (29), kaempferol (13), epicatechin (6), coumaric acid (30), and caffeic acid (31) (Figure 2) [36]. Additionally, camphor (32), phytol (33), hexadecane (34), and vitamin E acetate (35) (Figure 2) were identified from leaf extract of the plant [21].

Different parts of this plant extracts were reported with antidiarrheal [37], antihyperglycemic [19, 30, 3840], antimicrobial [21], anti-inflammatory [41], antipyretic [42], antioxidant [43, 44], antiulcer [45], hepatoprotective [27, 46], and immunomodulatory [17] activity. Additionally, Acacia species extracts also show antiviral activity against dengue virus [47, 48], human immunodeficiency virus (HIV) [49, 50], herpes simplex virus [49], and hepatitis B and C virus [51, 52]. Different phytochemicals present in plant extract are responsible for the diverse bioactivities (Figure 1).

3.1. Antidiabetic Activities

A. catechu extracts show an antidiabetic activity with IC50 of 49.9 μg/mL towards porcine pancreatic α-amylase [53] and 0.4977 mg/mL against α-glucosidase [54]. In another study, it was found that methanol extract of A. catechu inhibits α-amylase activity with an IC50 of 49.9 ± 0.4 μg/mL, and kinetic study shows that extract exhibits the mixed type of inhibition [53]. Catechin (5), epicatechin (6), gallocatechin (36), epigallocatechin (37), procyanidin B1 (38), procyanidin B3 (39), emodin (40), afzelechin (8), epiafzelechin (9), maclurin (41), irisflorentin (42), naringenin (43), isoquercetin (44), diosmetin (45), chrysin (46), myricetin (47), kaempferol (13), avicularin (48), prodelphinidin B (49), prodelphinidin B3 (50), quercetin (16), taxifolin (51), acacetin (52), aciculatinone (53), gossypin (54), pterocarpan (55), isorhamnetin (56), and trihydroxy dimethoxyflavone (57) (Figure 3) were identified from A. catechu through liquid chromatography-high resolution mass spectrometry (LC-HRMS) based molecular annotation which was responsible for inhibitory activities of α-glucosidase and α-amylase with an IC50 of 10.3–174.7 μg/mL [55]. Dichloromethane, ethyl acetate, aqueous fractions, and methanolic crude extract of A. catechu bark showed inhibitory activities of α-glucosidase and α-amylase with IC50 ranges of 9–115 μg/mL [56], and catechin, epicatechin, gallocatechin, epigallocatechin, procyanidin, and emodin were identified from ethyl acetate and aqueous fractions through LC-HRMS [56].

A study showed the improvement of glucose tolerance on feeding ethanolic extracts of A. catechu to streptozotocin- (STZ-) induced diabetic rats by 22% and 27% after 7 and 14 days, respectively, and 17% and 26% in the high-fructose high-fat diet- (HFD-) fed low-dosed STZ-treated rats [57]. Additionally, ethanolic and aqueous extracts were shown with an IC50 of 9.30 μg/mL and 4.70 μg/mL against normal eye lens, while that against the eye lens enzyme from STZ-induced diabetic rats was 9.08 μg/mL and 4.91 μg/mL, showing an ability in the management of diabetic complications [57]. The antidiabetic activity of the plant extracts was shown via the reduction of enzymatic activities of α-glucosidase, α-amylase, and aldose reductase.

3.2. Antioxidant Activities

A. catechu showed antioxidant ability as evident with 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities (IC50 : 15.52 ± 0.46 μg/mL), hydroxyl radical scavenging capacities (IC50 : 121.20 ± 1.22 μg/mL), superoxide radical scavenging activities (IC50 : 131.900 ± 4.40 μg/mL), singlet oxygen scavenging capacities (IC50 : 1103.79 ± 24.69 μg/mL), nitric oxide scavenging activities (IC50 : 45.57 ± 1.33 μg/mL), peroxynitrite scavenging activities (IC50 : 854.05 ± 59.96 μg/mL), hypochlorous acid scavenging activities (IC50 value: 130.675 ± 4.78 μg/mL), and iron- (Fe2+-) chelation activities (IC50 : 320.63 ± 10.82 μg/mL) [58]. Moreover, methanol extract of A. catechu showed DPPH radical and ABTS (2,2-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)) radical scavenging activities (IC50 : 101.74 and 140.41 μg/mL), superoxide radical and peroxyl radical scavenging activities (IC50 : 175.90 and 152.76 μg/mL), and cupric ion and ferric ion reducing power (IC50 : 184.30 and 232.13 μg/mL) [36]. Similarly, the methanol, ethanol, butanol, and aqueous fractions of A. catechu showed an antioxidant property with IC50 ranges of 92.48–529.30 μg/mL on DPPH radical, ABTS radical, superoxide radical scavenging assays, and cupric ion and ferric ion reducing assays mainly due to the presence of quercetin (16), kaempferol (13), and chlorogenic acid (28) (Figure 2) [13].

A. catechu showed the antioxidant potential through oxygen radical absorbance capacity (41589 ± 151.30 μMTE/g), DPPH scavenging assay (IC50 = 7.40 ± 1.16 μg/mL), ABTS radical scavenging assay (IC50 = 2.28 ± 0.14 μg/mL), and cellular antioxidant activity (EC50 = 230.50 ± 6.40 μg/mL) [27]. Ethanol and methanol extracts of A. catechu barks showed the DPPH radical scavenging ability of 23.76 ± 1.57 and 84.9 ± 1.9 μg/mL, respectively [55, 56]. In other research, methanol extract of A. catechu showed antioxidant activity with an IC50 value of 1.3 μg/mL [59]. Additionally, the antioxidant ability of methanol and aqueous extracts of A. catechu was shown through DPPH radical and ABTS radical scavenging assays, ferric reducing power assays, superoxide radical scavenging assays, and lipid peroxidation with an IC50 of 48.65–54.44 mg of equivalents/g powder [44]. Oxidative stress arises due to excessive free radicals, and reactive oxygen species are managed by the metabolites, especially polyphenols from plant extracts, which also further provide aid on the management of diabetes [55, 56, 60, 61].

3.3. Antimicrobial Activities

Aqueous extracts of A. catechu exhibited an antimicrobial effect against Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli, and Klebsiella pneumonia with a diameter of zone of inhibition (ZoI) of 17.66 ± 1.52, 16.66 ± 1.15, 14.0 ± 2.0, 8.33 ± 0.57, and 8.0 ± 0.0 mm, respectively [62]. The aqueous extract of A. catechu resin exhibits an inhibitory effect against Bacillus subtilis (MIC: 20 μg/mL), S. aureus (MIC: 40 μg/mL), P. aeruginosa (MIC: 220 μg/mL), and E. coli (MIC: 330 μg/mL) [9]. Similarly, Negi and Dave showed antimicrobial activities of methanol extract of A. catechu leaves with an MIC of 1,000 µg/mL against Gram-positive bacteria S. aureus and B. subtilis, while that for Gram-negative Salmonella typhimurium, E. coli, and P. aeruginosa were 700, 1,500, and ≤2,000 μg/mL, respectively [21]. A study on the heartwood of plants from Nepal showed significant antibacterial activity of its ethyl acetate extract with an MBC of 50 mg/mL against B. subtilis and Shigella sp. and that against K. pneumonia and S. aureus was 100 mg/mL [63]. The methanol extract of the plant showed antibacterial activity with a diameter of ZoI of 18, 15, 14, and 12 mm against E. coli, S. aureus, methicillin-resistant S. aureus, and Acinetobacter baumannii, respectively [59]. The aqueous fraction of bark showed antibacterial activity against S. aureus with an MIC and MBC of 6.25 and 12.5 mg/mL [55, 56]. A. catechu was shown effective than chlorhexidine, an antibacterial agent which has been used in the treatment of gingivitis [64, 65].

Patel et al. highlight the high contents of catechin and epicatechin which are responsible for antibacterial activity [9]. Additionally, taxifolin (51) isolated from leaves extracts showed an inhibitory effect against Streptococcus mutans and Lactobacillus acidophilus with a ZoI of 23 and 14.5 mm, respectively, at 2.5 mg/mL [66]. Nonetheless, metabolites such as acthaside [67], betulinic acid-3-trans-caffeate [68], methyl gallate [69], naringenin (43) (Figure 3), quercetin (16), kaempferol (13) (Figure 2) [70], 3-O-[β-D-xylopyranosyl-(1⟶4)-β-D-galactopyranosyl]-oleanolic acid, and 3-O-[β-galactopyranosyl-(1⟶4)-β-D-galactopyranosyl]-oleanolic acid [71] from different Acacia species have been shown with antimicrobial activity. These sorts of evidence support that A. catechu being rich in bioactive secondary metabolites could be a promising material for research in drug discovery of antimicrobial agents.

3.4. Anticancer Activities

A. catechu seed extract inhibits the active proliferation of human oral squamous cell carcinoma SCC-25 cells via the increment on the expression of apoptotic markers caspases 8 and 9, cytochrome c, and proapoptotic proteins (Bax gene) and significant downregulation of antiapoptotic genes (Bcl-2) [72]. It showed cytotoxicity with an IC50 of 100 μg/mL on SCC-25 cells [72]. Methanolic extract of A. catechu showed the antiproliferative activity by inducing apoptosis to human breast adenocarcinoma MCF-7 cells through the activation of caspase-cascade and cleavage of poly-adeno ribose polymerase due to increased Bax/Bcl-2 ratio [73]. Moreover, A. catechu extracts rich in catechin showed anticancer activity towards the human breast adenocarcinoma cell line (MCF-7) via regulating the expression of transcription factors NF-κB (initiation and progression of cancer), p53 (organizes and directs cellular responses), and AP-1 (involved in cell differentiation and proliferation) and nitric oxide levels [74]. Similarly, its extract induces apoptosis to human colorectal adenocarcinoma HT-29 cells and increases caspase-9 and 3 activities [31]. The ethanol extract of A. catechu showed concentration-dependent inhibition in the proliferation of human lung (A549), prostate (PC-3), breast (T47D and MCF-7), colon (HCT-16, Colo-205), and leukemia (THP-1, HL-60, and K562) cancer cells with cytotoxicity ranges of 9.0–42.8 μg/mL [75]. Additionally, the ethyl acetate fraction of this plant was responsible for 50% inhibition in the growth of cancer line cells at 153.23 μg/mL in lung cancer cell line (A549), 163.97 μg/mL in cervix cancer cell line (HeLa), 186.19 μg/mL in a prostate cancer cell line (PC-3), 204.67 μg/mL in liver cancer cell line (HepG2), and 251.33 μg/mL in brain cancer cell line (IMR32) [13]. This ethyl acetate fraction has most potent activity towards breast cancer cell line (MCF-7) with an IC50 of 137.5 μg/mL. Nonetheless, the methanol extract inhibits the growth of lung cancer cell line (A549) with an IC50 value of 184.52 μg/mL, while a butanol fraction and an aqueous fraction inhibit cervix cancer cell line (HeLa) with an IC50 value of 186.51 μg/ml and 241.30 μg/ml, respectively [13].

3.5. Antiviral Activities

On cell-free virus-based assay using reporter-gene-based TZM-bl cells and HIV-1NL4.3 (X-4 tropic), the aqueous, 50% ethanolic, and butanol extracts of A. catechu showed anti-HIV-1 activities with IC50 values of 1.8 ± 0.18, 3.6 ± 0.31, and 1.7 ± 0.12 μg/mL, respectively, probably by inhibiting the activities of the viral protease and Tat [50]. The butanol fraction shows anti-HIV protease activity with an IC50 of 12.9 μg/mL. Antiviral activity is via blockage of RNA synthesis and inhibition of assembling and maturation of virus particles in infected cells [50].

Peptides extracted from A. catechu exhibit the inhibition of dengue virus (DENV) foci formation (IC50 = 0.18 μg/mL), inhibit early infections, and were effective against all four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) [48]. Nonetheless, the peptide extract (1.25 μg/mL) also reduces the virus production with no cell toxicity by around 100-fold [48]. In recent days, antiviral compounds from natural products were assayed for their roles in the management of the current pandemic, coronavirus-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1, 7678]. The immunomodulatory activity of A. catechu [17] also makes it a probable candidate against COVID-19 [79].

3.6. Antidiarrheal Activities

In an in vitro study in Guinea Pig, A. catechu extract showed beneficial activities towards diarrhea patients via spasmolytic and antispastic activities through interaction with calcium channels and muscarinic receptors [37]. Extract of plant showed a noncompetitive reversible antagonism to carbachol in proximal colon (IC50 = 0.74 mg/mL) and ileum segments (IC50 = 0.98 mg/mL) [37]. In another study, bark extract of plant showed a significant () concentration-dependent antidiarrheal activity through castor oil-induced diarrhea experiment [26]. During the experiment, extracts (200 mg/kg and 250 mg/kg) showed a reduction of diarrhea by 20 and 40% [26].

3.7. Anti-Inflammatory Activities

Nitric oxide is useful for several physiological functions, but overproduction results in inflammatory diseases [80, 81]. A. catechu controls the production of nitric oxide by peritoneal macrophages in a dose-dependent manner [17]. A. catechu increases the secretion of IL-10 (plays a role in immunoregulation and inflammation) and inhibits the production of TNF-α (mediator of inflammatory response) secreted by monocytes and macrophages [17].

Natural flavonoid from Scutellaria baicalensis (baicalin) and A. catechu (catechin) inhibited the activities of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and 5-lipoxygenase (5-LOX) enzymes responsible for the production of eicosanoids and reduced the expressions of nuclear factor-kappa B (NF-kB), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase [41, 82, 83]. Extracts of A. catechu in combination with extracts of S. baicalensis were shown with the inhibiting ability of cyclooxygenase and 5-lipoxygenase which are important in the production of inflammatory cytokines from arachidonic acid [82, 84]. The expression of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 were decreased by the mixture of extracts [41, 82, 84, 85].

3.8. Hepatoprotective Activities

A study showed the inhibiting ability of ethyl acetate extract of A. catechu (250 mg/kg) towards tetrachloride-induced liver toxicity in albino rats through biochemical (estimation of serum transaminase, serum alkaline phosphatase, and serum bilirubin) and histopathological values [86]. A. catechu herbal extracts were shown as hepatoprotective with the IC50 of 114.8 μg/mL on HepG2 cells toxified with tert-butyl hydroperoxide (t-BH) [27]. The antioxidant potential of this plant attributed hepatoprotective activity via diminishing lipid peroxidation and cellular damage [27]. Similarly, from an in vivo model, ethyl acetate extract of the plant showed significant hepatoprotective ability [42]. Nonetheless, the seed and bark extract of A. catechu showed hepatoprotective activity via decreasing lipid peroxidation, reducing the activity of liver enzymes (alanine aminotransferase, alkaline phosphatase, and aspartate aminotransferase), and increasing the antioxidant activity through an increase in activities of glutathione and superoxide dismutase in Wistar rat model experiments [87].

3.9. Immunomodulatory Activities

Upon treatment of extracts of A. catechu, the number of antibody-producing cells in the spleen increased with 535.67 ± 1.69 and 370.50 ± 1.33 plaque-forming cells (PFC)/106 spleen cells for ethanol and aqueous extracts at 200 mg/kg [17]. The butanol fraction of plant extract rich in catechins was shown with beneficial abilities on the immune system [28]. Another study showed the increment of serum immunoglobulin levels and hemagglutination titer values, and the decrease in the mortality rate on feeding the plant extracts to mice results in the immunomodulatory activity [88].

3.10. Additional Applications
3.10.1. Antiulcer

Aqueous extract of A. catechu showed a significant reduction in total acidity, number of ulcers, volume of gastric juices, and the activity probably due to action on the membrane of microorganism, by the accumulation of mucus, by inhibiting H + K(+)-ATPase, and by decreasing mucosal hemorrhage and erosion [45]. Also, tablets prepared from A. catechu extracts were effective in the prevention and/or treatment of mouth ulcers [89].

3.10.2. Antinociceptive

A. catechu exhibited the dose-dependent antinociceptive activity probably due to blockage of prostaglandins synthesis by extracts which might be effected through the inhibition of activities of cyclooxygenase and lipoxygenase [19].

3.10.3. Antipyretic

In albino rats, ethyl acetate extract of A. catechu was shown with antipyretic activity () at a concentration of 250 and 500 mg/kg [42]. Similarly, Dubey et al. showed the antipyretic activity of the hydroalcoholic leaf extract of the plant [90].

3.10.4. Neurodegenerative Disorders

The methanol extract of A. catechu showed potential in the management of neurodegenerative diseases (Alzheimer's disease) via the anticholinesterase effect and significant antioxidant effect [91]. Also, the water extract of the plant stem shows acetylcholinesterase (AChE) inhibitory activity with an IC50 of 0.95 mg/mL [92].

3.10.5. Wound Healing

The plant extract showed wound healing activities on the excisional wound model with a significant increase in collagen and granulation tissue on day 21 in guinea pigs [93].

The development of bioactive compounds with pharmacological functions as a drug depends upon their pharmacological parameters such as absorption, distribution, metabolism, excretion, and toxicity properties. A study showed the ethanolic extract of A. catechu seed with low mammalian toxicity through hematological and biochemical parameters analysis [94]. Additionally, Lakshmi et al. showed that ethanolic seed extract of the plant plant with marked cytotoxic effect on brine shrimps assays [95]. Further in vivo and/or clinical assays are required to explore them as a potent drug.

4. Conclusions

A. catechu being a rich source of bioactive secondary metabolites, especially polyphenols, could be a promising material for research in drug discovery against different diseases. The plant was shown with wide pharmacological functions such as antioxidants, antidiabetic, antimicrobial, anti-inflammatory, antiviral, and anticancer abilities. Further research is required to evaluate the plant extracts and their active bioactive compounds as drugs or food compliments.

Abbreviations

ABTS:2,2-Azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)
DENV:Dengue virus
DM:Diabetes mellitus
DPP-IV:Dipeptidyl peptidase-IV
DPPH:2,2-Diphenyl-1-picrylhydrazyl
EC50:Half maximal effective concentration
IC50:Half maximal inhibitory concentration
IDF:International Diabetes Federation
LC-HRMS: Liquid chromatography-high resolution mass spectrometry
STZ:Streptozotocin
ZoI:Zone of inhibition.

Conflicts of Interest

The authors declare no potential conflicts of interest.

Authors’ Contributions

B. Adhikari designed the concept; B. Adhikari, B. Aryal, and B. R. Bhattarai performed the literature surveys, prepared the draft, and performed all revisions and edits on the manuscript.

Acknowledgments

The authors would like to thanks all professors and staff from the Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal, for their assistance in the research.

References

  1. B. Adhikari, B. P. Marasini, B. Rayamajhee et al., “Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID ‐19: a review,” Phytotherapy Research, vol. 35, no. 3, pp. 1298–1312, 2021. View at: Publisher Site | Google Scholar
  2. A. Sofowora, E. Ogunbodede, and A. Onayade, “The role and place of medicinal plants in the strategies for disease prevention,” African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM, vol. 10, pp. 210–229, 2013. View at: Publisher Site | Google Scholar
  3. M. L. Willcox, M. J. Cosentino, R. Pink, S. Wayling, and G. Bodeker, “Natural products for the treatment of tropical diseases,” Trends in Parasitology, vol. 17, no. 2, pp. 58–60, 2001. View at: Publisher Site | Google Scholar
  4. C. R. Pye, M. J. Bertin, R. S. Lokey, W. H. Gerwick, and R. G. Linington, “Retrospective analysis of natural products provides insights for future discovery trends,” Proceedings of the National Academy of Sciences, vol. 114, no. 22, pp. 5601–5606, 2017. View at: Publisher Site | Google Scholar
  5. A. Karimi, M. Majlesi, and M. Rafieian-Kopaei, “Herbal versus synthetic drugs; beliefs and facts,” J Nephropharmacol, vol. 4, pp. 27–30, 2015. View at: Google Scholar
  6. A. G. Atanasov, S. B. Zotchev, S. B. Zotchev, V. M. Dirsch, and C. T. Supuran, “Natural products in drug discovery: advances and opportunities,” Nature Reviews Drug Discovery, vol. 20, no. 3, pp. 200–216, 2021. View at: Publisher Site | Google Scholar
  7. S.-Y. Pan, S.-F. Zhou, S.-H. Gao et al., “New perspectives on how to discover drugs from herbal medicines: CAM’s outstanding contribution to modern therapeutics,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID e627375, 2013. View at: Publisher Site | Google Scholar
  8. J. B. Calixto, “The role of natural products in modern drug discovery,” Anais da Academia Brasileira de Ciências, vol. 91, no. suppl 3, 2019. View at: Publisher Site | Google Scholar
  9. J. D. Patel, V. Kumar, and S. A. Bhatt, “Antimicrobial screening and phytochemical analysis of the resin part of Acacia catechu,” Pharmaceutical Biology, vol. 47, no. 1, pp. 34–37, 2009. View at: Publisher Site | Google Scholar
  10. A. V. Thakur, S. Ambwani, and T. K. Ambwani, “Preliminary phytochemical screening and GC-MS analysis of leaf extract of Acacia catechu (Lf) Willd,” International Journal of Herbal Medicine, vol. 6, pp. 81–85, 2018, https://www.florajournal.com/archives/2018/vol6issue2/PartB/7-1-15-894.pdf. View at: Google Scholar
  11. R. Bhattarai, P. Sharma, B. Wagle, A. Adhikari, and S. Acharya, “Revision and compilation of health management plan of Khair (Acacia catechu),” Grassroots Journal of Natural Resources, vol. 3, no. 1, pp. 15–28, 2020. View at: Publisher Site | Google Scholar
  12. L. Thangavelu, S. R. Balusamy, R. Shanmugam et al., “Evaluation of the sub-acute toxicity of Acacia catechu Willd seed extract in a Wistar albino rat model,” Regulatory Toxicology and Pharmacology, vol. 113, Article ID 104640, 2020. View at: Publisher Site | Google Scholar
  13. R. Kumar, S. Mahey, R. Arora, J. Mahajan, V. Kumar, and S. Arora, “Insights into biological properties of less explored bark of industrially important Acacia catechu Willd,” Industrial Crops and Products, vol. 138, Article ID 111486, 2019. View at: Publisher Site | Google Scholar
  14. R. M. Kunwar, K. P. Shrestha, and R. W. Bussmann, “Traditional herbal medicine in Far-west Nepal: a pharmacological appraisal,” Journal of Ethnobiology and Ethnomedicine, vol. 6, no. 1, p. 35, 2010. View at: Publisher Site | Google Scholar
  15. K. S. Babasaheb, P. T. Arif, and S. S. Shaligram, “Phytopharmacology of Acacia catechu Willd: a review,” European Journal of Pharmaceutical and Medical Research, vol. 6, pp. 216–223, 2019. View at: Google Scholar
  16. D. Shen, Q. Wu, M. Wang, Y. Yang, E. J. Lavoie, and J. E. Simon, “Determination of the predominant catechins in Acacia catechu by liquid chromatography/electrospray Ionization−Mass spectrometry,” Journal of Agricultural and Food Chemistry, vol. 54, no. 9, pp. 3219–3224, 2006. View at: Publisher Site | Google Scholar
  17. M. A. Sunil, V. S. Sunitha, E. K. Radhakrishnan, and M. Jyothis, “Immunomodulatory activities of Acacia catechu, a traditional thirst quencher of South India,” Journal of Ayurveda and Integrative Medicine, vol. 10, no. 3, pp. 185–191, 2019. View at: Publisher Site | Google Scholar
  18. N. P. Manandhar, Plants and People of Nepal, Timber Press, Portland, OR, USA, 2002, https://www.cabdirect.org/cabdirect/abstract/20023098128.
  19. M. Rahmatullah, M. Hossain, A. Mahmud et al., “Antihyperglycemic and antinociceptive activity evaluation of 'Khoyer' prepared from boiling the wood of Acacia catechu in water,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 10, no. 4, pp. 1–5, 2013. View at: Publisher Site | Google Scholar
  20. S. Rout, G. Sahoo, U. N. Mishra, A. Sheera, and A. K. Prusty, “An Overview of Acacia catechu,” Biotica Research Today, vol. 3, pp. 691–693, 2021. View at: Google Scholar
  21. B. S. Negi and B. P. Dave, “In vitro antimicrobial activity of Acacia catechu and its phytochemical analysis,” Indian Journal of Microbiology, vol. 50, no. 4, pp. 369–374, 2010. View at: Publisher Site | Google Scholar
  22. S. J. Stohs and D. Bagchi, “Antioxidant, anti‐inflammatory, and chemoprotective properties of Acacia catechu heartwood extracts,” Phytotherapy Research, vol. 29, no. 6, pp. 818–824, 2015. View at: Publisher Site | Google Scholar
  23. P. Sharma and R. Lingha, “A recent update on the pharmacognostical as well as pharmacological profiles of the Acacia catechu heartwood: a mini review,” Journal of Ayurveda and Holistic Medicine, vol. 7, pp. 188–192, 2021. View at: Google Scholar
  24. J. Klepacka, E. Gujska, and J. Michalak, “Phenolic compounds as cultivar- and variety-distinguishing factors in some plant products,” Plant Foods for Human Nutrition, vol. 66, no. 1, pp. 64–69, 2011. View at: Publisher Site | Google Scholar
  25. B. Hazra, R. Sarkar, S. Biswas, and N. Mandal, “The antioxidant, iron chelating and DNA protective properties of 70% methanolic extract of “katha” (heartwood extract of Acacia catechu),” Journal of Complementary and Integrative Medicine, vol. 7, 2010. View at: Publisher Site | Google Scholar
  26. M. Singh, V. Raj, and A. Rai, “Detection of bioflavonoids from methanol bark extracts of Acacia and their role as antidiarrhoeal agents,” Journal of Analytical & Pharmaceutical Research, vol. 5, Article ID 00146, 2017. View at: Publisher Site | Google Scholar
  27. B. D. Hiraganahalli, V. C. Chinampudur, S. Dethe et al., “Hepatoprotective and antioxidant activity of standardized herbal extracts,” Pharmacognosy Magazine, vol. 8, pp. 116–123, 2012. View at: Publisher Site | Google Scholar
  28. M. A. Sunil, V. S. Sunitha, A. Ashitha et al., “Catechin rich butanol fraction extracted from Acacia catechu L. (a thirst quencher) exhibits immunostimulatory potential,” Journal of Food and Drug Analysis, vol. 27, no. 1, pp. 195–207, 2019. View at: Publisher Site | Google Scholar
  29. A. V. Thakur, S. Ambwani, and T. K. Ambwani, “Preliminary phytochemical screening and GC-MS analysis of leaf extract of Acacia catechu (lf) wild,” International Journal of Herbal Medicine, vol. 6, pp. 81–85, 2018. View at: Google Scholar
  30. N. Gunindro, K. P. Devi, and T. I. Singh, “Effects of Acacia catechu on intestinal absorption of glucose in rats,” J Chem Pharm Res, vol. 5, pp. 78–81, 2013. View at: Google Scholar
  31. E. Chiaino, M. Micucci, M. Durante et al., “Apoptotic-induced effects of Acacia catechu Willd. Extract in human colon cancer cells,” International Journal of Molecular Sciences, vol. 21, no. 6, Article ID 2102, 2020. View at: Publisher Site | Google Scholar
  32. X. Li, H. Wang, C. Liu, and R. Chen, “Chemical constituents of Acacia catechu,” Zhongguo Zhong Yao Za Zhi= Zhongguo Zhongyao Zazhi= China Journal of Chinese Materia Medica, vol. 35, pp. 1425–1427, 2010. View at: Publisher Site | Google Scholar
  33. L. Wang, X. Shen, L. Mi et al., “Simultaneous determinations of four major bioactive components in Acacia catechu (L.f.) Willd and Scutellaria baicalensis Georgi extracts by LC-MS/MS: application to its herb-herb interactions based on pharmacokinetic, tissue distribution and excretion studies in rats,” Phytomedicine, vol. 56, pp. 64–73, 2019. View at: Publisher Site | Google Scholar
  34. S. S. Hong, Y.-H. Choi, H.-J. Suh et al., “Flavonoid constituents of Acacia catechu,” Journal of Applied Biological Chemistry, vol. 58, no. 2, pp. 189–194, 2015. View at: Publisher Site | Google Scholar
  35. X.-C. Li, C. Liu, L.-X. Yang, and R.-Y. Chen, “Phenolic compounds from the aqueous extract of Acacia catechu,” Journal of Asian Natural Products Research, vol. 13, no. 9, pp. 826–830, 2011. View at: Publisher Site | Google Scholar
  36. R. Kumar, R. Arora, J. Mahajan, S. Mahey, and S. Arora, “Polyphenols from cutch tree (Acacia catechu Willd.): normalize in vitro oxidative stress and exerts antiproliferative activity,” Brazilian Archives of Biology and Technology, vol. 61, 2018. View at: Publisher Site | Google Scholar
  37. M. Micucci, R. Gotti, I. Corazza et al., “Newer insights into the antidiarrheal effects of Acacia catechu Willd. Extract in Guinea pig,” Journal of Medicinal Food, vol. 20, no. 6, pp. 592–600, 2017. View at: Publisher Site | Google Scholar
  38. V. Bhatia, S. P. Srivastava, R. Srivastava et al., “Antihyperglycaemic and aldose reductase inhibitory potential of Acacia catechu hard wood and Tectona grandis leaves,” Medicinal Chemistry Research, vol. 20, no. 9, pp. 1724–1731, 2011. View at: Publisher Site | Google Scholar
  39. N. K. Agrawal and U. Gupta, “Evaluation of hypoglycemic and antihyperglycemic effects of Acacia tortilis seed extract in normal and diabetic rats,” International Journal of PharmTech Research, vol. 5, pp. 330–336, 2013. View at: Google Scholar
  40. M. Yasir, P. Jain, D. Debajyoti, and M. D. Kharya, “Hypoglycemic and antihyperglycemic effect of different extracts of Acacia arabica lamk bark in normal and alloxan induced diabetic rats,” International Journal of Phytomedicine, vol. 2, 2010. View at: Publisher Site | Google Scholar
  41. M. Yimam, L. Brownell, M. Hodges, and Q. Jia, “Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu,” Journal of Dietary Supplements, vol. 9, no. 3, pp. 155–165, 2012. View at: Publisher Site | Google Scholar
  42. D. Ray, K. H. Sharatchandra, and I. Thokchom, “Antipyretic, antidiarrhoeal, hypoglycaemic and hepatoprotective activities of ethyl acetate extract of Acacia catechu Willd.in albino rats,” Indian Journal of Pharmacology, vol. 38, no. 6, p. 408, 2006, https://www.ijp-online.com/text.asp?2006/38/6/408/28207. View at: Publisher Site | Google Scholar
  43. T. Lakshmi, R. Ramasamy, and R. Thirumalaikumaran, “Preliminary Phytochemical analysis and in vitro Antioxidant, FTIR Spectroscopy, Anti-diabetic activity of Acacia catechu ethanolic seed extract,” Pharmacognosy Journal, vol. 7, no. 6, pp. 356–362, 2015. View at: Publisher Site | Google Scholar
  44. A. Patil and M. Modak, “Comparative evaluation of oxidative stress modulating and DNA protective activities of aqueous and methanolic extracts of Acacia catechu,” Medicines (Basel, Switzerland), vol. 4, 2017. View at: Publisher Site | Google Scholar
  45. R. Patankar, T. Devale, R. Pophale, V. Gawande, and N. Raghav, “Antiulcer activity of Acacia catechu Willd in rats,” International Journal of Research in Ayurveda and Pharmacy (IJRAP), vol. 2, pp. 1585–1587, 2011. View at: Google Scholar
  46. U. Waseem, A. Waseem, N. Majeed, F. Qureshi, M. Q. Muneer, and S. R. Jafri, “Gastroprotective effects of plants extracts: Acacia catechu on gastric mucosal injury in experimental albino rats model,” International Journal of Basic & Clinical Pharmacology, vol. 10, no. 4, pp. 347–352, 2021. View at: Publisher Site | Google Scholar
  47. S. Y. M. Lim, J. Y. Chieng, and Y. Pan, “Recent insights on anti-dengue virus (DENV) medicinal plants: review onin vitro,in vivoandin silicodiscoveries,” All Life, vol. 14, no. 1, pp. 1–33, 2021. View at: Publisher Site | Google Scholar
  48. A. Panya, P. Yongpitakwattana, P. Budchart et al., “Novel bioactive peptides demonstrating anti-dengue virus activity isolated from the Asian medicinal plant Acacia Catechu,” Chemical Biology & Drug Design, vol. 93, no. 2, pp. 100–109, 2019. View at: Publisher Site | Google Scholar
  49. N. N. Mishra, A. Kesharwani, A. Agarwal, S. K. Polachira, R. Nair, and S. K. Gupta, “Herbal gel formulation developed for anti-human immunodeficiency virus (HIV)-1 activity also inhibits in vitro HSV-2 infection,” Viruses, vol. 10, 2018. View at: Publisher Site | Google Scholar
  50. N. Nutan, M. Modi, C. S. Dezzutti et al., “Extracts from Acacia catechu suppress HIV-1 replication by inhibiting the activities of the viral protease and Tat,” Virology Journal, vol. 10, p. 309, 2013. View at: Publisher Site | Google Scholar
  51. A. H. Arbab, M. K. Parvez, M. S. Al-Dosari et al., “Hepatoprotective and antiviral efficacy of Acacia mellifera leaves fractions against hepatitis B virus,” BioMed Research International, vol. 2015, Article ID 929131, 2015. View at: Publisher Site | Google Scholar
  52. S. Rehman, U. A. Ashfaq, S. Riaz, T. Javed, and S. Riazuddin, “Antiviral activity of Acacia nilotica against Hepatitis C Virus in liver infected cells,” Virology Journal, vol. 8, no. 1, p. 220, 2011. View at: Publisher Site | Google Scholar
  53. K. Khadayat, B. P. Marasini, H. Gautam, S. Ghaju, and N. Parajuli, “Evaluation of the alpha-amylase inhibitory activity of Nepalese medicinal plants used in the treatment of diabetes mellitus,” Clinical Phytoscience, vol. 6, no. 1, p. 34, 2020. View at: Publisher Site | Google Scholar
  54. T. Tunsaringkarn, A. Rungsiyothin, and N. Ruangrungsi, “α-Glucosidase inhibitory activity of water soluble extract from Thai mimosaceous plants,” Public Health Journal Burapha University, vol. 4, pp. 54–63, 2009, https://www.tci-thaijo.org/index.php/phjbuu/article/view/45607. View at: Google Scholar
  55. B. Aryal, B. Adhikari, N. Aryal, B. R. Bhattarai, K. Khadayat, and N. Parajuli, “LC-HRMS profiling and antidiabetic, antioxidant, and antibacterial activities of Acacia catechu (L.f.) Willd,” . BioMed Research International., vol. 2021, Article ID e7588711, 2021. View at: Publisher Site | Google Scholar
  56. B. Aryal, P. Niraula, K. Khadayat et al., “Antidiabetic, antimicrobial, and molecular profiling of selected medicinal plants,” Evidence-based Complementary and Alternative Medicine: eCAM, vol. 2021, Article ID 5510099, 2021. View at: Publisher Site | Google Scholar
  57. S. P. Srivastava, A. Mishra, V. Bhatia, T. Narender, and A. K. Srivastava, “Acacia catechu hard wood: potential anti-diabetic cum anti-dyslipidemic,” Medicinal Chemistry Research, vol. 20, no. 9, pp. 1732–1739, 2011. View at: Publisher Site | Google Scholar
  58. M. R. Saha, P. Dey, S. Begum et al., “Effect of Acacia catechu (L.f.) Willd. On oxidative stress with possible implications in alleviating selected cognitive disorders,” PLoS ONE, vol. 11, no. 3, Article ID e0150574, 2016. View at: Publisher Site | Google Scholar
  59. S. Shresta, S. Bhandari, B. Aryal et al., “Evaluation of phytochemical, antioxidant and antibacterial activities of selected medicinal plants,” Nepal Journal of Biotechnology, vol. 9, no. 1, pp. 50–62, 2021. View at: Publisher Site | Google Scholar
  60. Y.-Z. Cai, M. Mei Sun, J. Jie Xing, Q. Luo, and H. Corke, “Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants,” Life Sciences, vol. 78, no. 25, pp. 2872–2888, 2006. View at: Publisher Site | Google Scholar
  61. D. Huang, B. Ou, and R. L. Prior, “The Chemistry behind antioxidant capacity assays,” Journal of Agricultural and Food Chemistry, vol. 53, no. 6, pp. 1841–1856, 2005. View at: Publisher Site | Google Scholar
  62. M. Dashtdar, M. R. Dashtdar, B. Dashtdar, M. k. shirazi, and S. A. Khan, “In-vitro, anti-bacterial activities of aqueous extracts of Acacia catechu (L.F.)Willd, castanea sativa, ephedra sinica stapf and shilajita mumiyo against Gram positive and Gram negative bacteria,” Journal of Pharmacopuncture, vol. 16, no. 2, pp. 15–22, 2013. View at: Publisher Site | Google Scholar
  63. S. Joshi, Y. P. Subedi, and S. K. Paudel, “Antibacterial and antifungal activity of heartwood of Acacia catechu of Nepal,” Journal of Nepal Chemical Society, vol. 27, pp. 94–99, 2011. View at: Publisher Site | Google Scholar
  64. S. C. Cortelli, J. R. Cortelli, H. Shang, J. A. McGuire, and C. A. Charles, “Long-term management of plaque and gingivitis using an alcohol-free essential oil containing mouthrinse: a 6-month randomized clinical trial,” American Journal of Dentistry, vol. 26, pp. 149–155, 2013. View at: Google Scholar
  65. S. G. Joshi, L. G. Shettar, L. G. Shettar, P. S. Agnihotri, A. B. Acharya, and S. L. Thakur, “Solanum xanthocarpum and Acacia catechu Willd- an ayurvedic soothe: a randomized clinical trial,” Journal of Ayurvedic and Herbal Medicine, vol. 7, no. 1, pp. 1–4, 2021. View at: Publisher Site | Google Scholar
  66. S. T. Ahamad, T. Lakshmi, S. Rajeshkumar, A. Roy, D. Gurunadhan, and R. Geetha, “Antibacterial activity of taxifolin isolated from Acacia catechu leaf extract-an invitro study,” Indian Journal of Public Health Research & Development, vol. 10, no. 11, p. 3540, 2019. View at: Publisher Site | Google Scholar
  67. A. M. O. Amoussa, M. Bourjot, L. Lagnika, C. Vonthron-Sénécheau, and A. Sanni, “Acthaside: a new chromone derivative from Acacia ataxacantha and its biological activities,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, p. 506, 2016. View at: Publisher Site | Google Scholar
  68. A. M. O. Amoussa, L. Lagnika, M. Bourjot, C. Vonthron-Senecheau, and A. Sanni, “Triterpenoids from Acacia ataxacantha DC: antimicrobial and antioxidant activities,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, p. 284, 2016. View at: Publisher Site | Google Scholar
  69. R. K. Mishra, M. Ramakrishna, V. Mishra et al., “Pharmaco-phylogenetic investigation of methyl gallate isolated from Acacia nilotica (L.) delile and its cytotoxic effect on NIH3T3 mouse fibroblast,” Current Pharmaceutical Biotechnology, vol. 17, no. 6, pp. 540–548, 2016. View at: Publisher Site | Google Scholar
  70. A. A. Al-Huqail, S. I. Behiry, M. Z. M. Salem, H. M. Ali, M. H. Siddiqui, and A. Z. M. Salem, “Antifungal, antibacterial, and antioxidant activities of Acacia saligna (labill.) H. L. Wendl. Flower extract: HPLC analysis of phenolic and flavonoid compounds,” Molecules (Basel, Switzerland), vol. 24, 2019. View at: Publisher Site | Google Scholar
  71. F. T. Mambe, J. Na-Iya, G. W. Fotso et al., “Antibacterial and antibiotic modifying potential of crude extracts, fractions, and compounds from Acacia polyacantha Willd. Against MDR gram-negative bacteria,” Evidence-based Complementary and Alternative Medicine: eCAM, vol. 2019, Article ID 7507549, 2019. View at: Publisher Site | Google Scholar
  72. T. Lakshmi, D. Ezhilarasan, U. Nagaich, and R. Vijayaragavan, “Acacia catechu ethanolic seed extract triggers apoptosis of SCC-25 cells,” Pharmacognosy Magazine, vol. 13, p. S405, 2017. View at: Publisher Site | Google Scholar
  73. N. B. Ghate, B. Hazra, R. Sarkar, and N. Mandal, “Heartwood extract of Acacia catechu induces apoptosis in human breast carcinoma by altering bax/bcl-2 ratio,” Pharmacognosy Magazine, vol. 10, pp. 27–33, 2014. View at: Publisher Site | Google Scholar
  74. J. Monga, C. S. Chauhan, and M. Sharma, “Human breast adenocarcinoma cytotoxicity and modulation of 7,12-Dimethylbenz[a]anthracene-Induced mammary carcinoma in balb/c mice by Acacia catechu (L.f.) wild heartwood,” Integrative Cancer Therapies, vol. 12, no. 4, pp. 347–362, 2013. View at: Publisher Site | Google Scholar
  75. K. A. Diab, S. K. Guru, S. Bhushan, and A. K. Saxena, “In vitro anticancer activities of Anogeissus latifolia, Terminalia bellerica, Acacia catechu and Moringa oleiferna Indian plants,” Asian Pacific Journal of Cancer Prevention, vol. 16, no. 15, pp. 6423–6428, 2015. View at: Publisher Site | Google Scholar
  76. G. Anywar, M. Akram, and M. A. Chishti, “African and asian medicinal plants as a repository for prospective antiviral metabolites against HIV-1 and sars CoV-2: a mini review,” Frontiers in Pharmacology, vol. 12, p. 2199, 2021. View at: Publisher Site | Google Scholar
  77. S. Ahmad, S. Zahiruddin, B. Parveen et al., “Indian medicinal plants and formulations and their potential against COVID-19-preclinical and clinical research,” Frontiers in Pharmacology, vol. 11, Article ID 578970, 2021. View at: Publisher Site | Google Scholar
  78. F. R. Bhuiyan, S. Howlader, T. Raihan, and M. Hasan, “Plants metabolites: possibility of natural therapeutics against the COVID-19 pandemic,” Frontiers in Medicine, vol. 7, p. 444, 2020. View at: Publisher Site | Google Scholar
  79. P. E. Jai Rexlin and A. Roy, “Antiviral treatment strategies in COVID-19,” International Journal of Current Research and Review, vol. 12, pp. 23–28, 2020. View at: Google Scholar
  80. J. N. Sharma, A. Al-Omran, and S. S. Parvathy, “Role of nitric oxide in inflammatory diseases,” Inflammopharmacology, vol. 15, no. 6, pp. 252–259, 2007. View at: Publisher Site | Google Scholar
  81. T. J. Guzik, R. Korbut, and T. Adamek-Guzik, “Nitric oxide and superoxide in inflammation and immune regulation,” Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society, vol. 54, pp. 469–487, 2003. View at: Google Scholar
  82. B. P. Burnett, Q. Jia, Y. Zhao, and R. M. Levy, “A medicinal extract of Scutellaria baicalensis and Acacia catechu Acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation,” Journal of Medicinal Food, vol. 10, no. 3, pp. 442–451, 2007. View at: Publisher Site | Google Scholar
  83. D. Altavilla, F. Squadrito, A. Bitto et al., “Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages,” British Journal of Pharmacology, vol. 157, no. 8, pp. 1410–1418, 2009. View at: Publisher Site | Google Scholar
  84. J. Tseng-Crank, S. Sung, Q. Jia et al., “A medicinal plant extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-stimulated gene expression in immune cells: a comprehensive genomic study using qpcr, elisa, and microarray,” Journal of Dietary Supplements, vol. 7, no. 3, pp. 253–272, 2010. View at: Publisher Site | Google Scholar
  85. M. Yimam, Y. Zhao, W. Ma, Q. Jia, S.-G. Do, and J.-H. Shin, “90-Day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats,” Food and Chemical Toxicology, vol. 48, no. 5, pp. 1202–1209, 2010. View at: Publisher Site | Google Scholar
  86. P. Jayasekhar, P. V. Mohanan, and K. Rathinam, “Hepatoprotective activity of ethyl acetate extract of Acacia catechu,” Indian Journal of Pharmacology, vol. 29, p. 426, 1997. View at: Google Scholar
  87. T. Lakshmi, B. Sri Renukadevi, S. Senthilkumar et al., “Seed and bark extracts of Acacia catechu protects liver from acetaminophen induced hepatotoxicity by modulating oxidative stress, antioxidant enzymes and liver function enzymes in Wistar rat model,” Biomedicine & Pharmacotherapy, vol. 108, pp. 838–844, 2018. View at: Publisher Site | Google Scholar
  88. S. Ismail and M. Asad, “Immunomodulatory activity of Acacia catechu,” Indian Journal of Physiology and Pharmacology, vol. 53, pp. 25–33, 2009. View at: Google Scholar
  89. P. Bhardwaj, K. Shailendra, D. S. Sharma et al., “Chewable tablets of Acacia catechu extract, an alternative to betel (paan) for mouth ulcers: formulation and in vitro evaluation,” Current Drug Delivery, vol. 18, no. 4, pp. 500–512, 2021. View at: Publisher Site | Google Scholar
  90. Y. Dubey, P. Budholiya, and C. K. Tyagi, “Phytochemical screening and in vivo antipyretic activity of the hydroalcoholic leaves extract of Acacia catechu,” International Journal of Pharmaceutical Research and Applications, vol. 5, p. 9, 2020. View at: Google Scholar
  91. E. Elmorsy, E. Elsharkawy, F. A. Alhumaydhi, and M. Salama, “The protective effect of Indian Catechu methanolic extract against aluminum chloride-induced neurotoxicity, A rodent model of Alzheimer's disease,” Heliyon, vol. 7, no. 2, Article ID e06269, 2021. View at: Publisher Site | Google Scholar
  92. G. Choudhir, S. Sharma, and P. Hariprasad, “A combinatorial approach to screen structurally diverse acetylcholinesterase inhibitory plant secondary metabolites targeting Alzheimer's disease,” Journal of Biomolecular Structure and Dynamics, vol. 0, pp. 1–14, 2021. View at: Publisher Site | Google Scholar
  93. S. Tangeti, P. Gabbita, R. R. Ponnaluri, and B. P. Kolasani, “Comparative study of wound healing effect of topical Acacia catechu extract and silver sulfadiazine on excisional wound model in Guinea pigs,” International Journal of Basic & Clinical Pharmacology, vol. 7, no. 12, p. 2347, 2018. View at: Publisher Site | Google Scholar
  94. L. Thangavelu, R. Vijayaragavan, P. Selvanadhan, and D. Ezhilarasan, “Acute oral toxicity study of ethanolic extract of Acacia catechu Willd. seed using hematological and biochemical parameters in wistar albino rat,” Toxicology International (Formerly Indian Journal of Toxicology), vol. 22, no. 2, pp. 58–64, 2015. View at: Publisher Site | Google Scholar
  95. T. A. R. Lakshmi, “Invitro cytotoxicity assay of Acacia catechu ethanolic seed extract using brine shrimp,” Journal of Complementary Medicine Research, vol. 11, pp. 89–92, 2020. View at: Google Scholar

Copyright © 2021 Bikash Adhikari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Related articles

No related content is available yet for this article.
 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder
Views1160
Downloads431
Citations

Related articles

No related content is available yet for this article.

Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.