Dinuclear Copper(I) Thiodiacetate Complex-Mediated Expeditious Synthesis of the Chlorine-Containing Cyclen-Cored 36-Glucose-Coated Glycodendrimer

Table 1

Optimization of catalysts for the synthesis of the glucodendron.

Entry	Catalytic condition	Temp (˚C)	Yield^a (%)	Time (h)
1	CuSO4.5H2O/NaAsc, THF/H2O (1 : 1)	55	80	12
2	CuSO4.5H2O/NaAsc, DCM/H2O (1 : 1)	rt	75	12
3	CuI/DIPEA, DCM^b	rt	72	12
4	[(PPh3)2Cu(μ-tda)Cu(PPh3)2].6H2O (9), DCM^b/DIPEA	rt	84	3

^aYield reported after column chromatography (SiO₂). ^bReaction under the anhydrous condition.