Journal of Chemistry / 2021 / Article / Tab 1 / Research Article
Development, Optimization, and Evaluation of Luliconazole Nanoemulgel for the Treatment of Fungal Infection Table 1 Box–Behnken statistical design: levels of three independent variables from the experimental runs along with the predicted responses on LUL-loaded nanoemulsion.
Batch Levels of independent variables Actual responses Predicted responses A (% v/v)B (% v/v)C (% v/v)Globule size (Y 1) (nm) Entrapment efficiency Y 2 (%) Globule size (Y 1) (nm) Entrapment efficiency Y 2 (%) F1 0 −1 1 20.62 85.23 24.13 85.3 F2 0 0 0 16.67 92.86 16.33 92.74 F3 1 1 0 87.32 93.51 88.96 93.94 F4 0 1 1 54.02 86.54 46.87 86.19 F5 0 0 0 15.77 93.46 16.33 92.74 F6 1 0 −1 53.61 95.34 55.48 94.98 F7 0 0 0 17.23 91.79 16.33 92.74 F8 0 0 0 15.89 92.44 16.33 92.74 F9 −1 0 −1 32.21 85.45 31.56 85.53 F10 1 −1 0 78.63 93.56 74.49 93.57 F11 1 0 1 42.18 94.48 42.81 94.4 F12 −1 −1 0 41.23 82.46 39.59 82.03 F13 −1 0 1 13.88 79.33 12.01 79.69 F14 −1 1 0 65.02 81.32 69.16 81.31 F15 0 −1 −1 43.57 89.22 45.84 89.57 F16 0 1 −1 65.79 88.39 62.28 88.32 F17 0 0 0 16.07 93.14 16.33 92.74 Independent variable Levels Low (–1) Medium (0) High (1) A = oil (% v/v )10 15 20 B = Smix (% v/v )35 45 55 C = homogenization time (min)10 15 20 Dependent variables Y 1 = globule size (nm)Y 2 = entrapment efficiency (%)