Development, Optimization, and Evaluation of Luliconazole Nanoemulgel for the Treatment of Fungal Infection

Table 1

Box–Behnken statistical design: levels of three independent variables from the experimental runs along with the predicted responses on LUL-loaded nanoemulsion.

Batch	Levels of independent variables			Actual responses		Predicted responses
	A (% v/v)	B (% v/v)	C (% v/v)	Globule size (Y1) (nm)	Entrapment efficiency Y2 (%)	Globule size (Y1) (nm)	Entrapment efficiency Y2 (%)
F1	0	−1	1	20.62	85.23	24.13	85.3
F2	0	0	0	16.67	92.86	16.33	92.74
F3	1	1	0	87.32	93.51	88.96	93.94
F4	0	1	1	54.02	86.54	46.87	86.19
F5	0	0	0	15.77	93.46	16.33	92.74
F6	1	0	−1	53.61	95.34	55.48	94.98
F7	0	0	0	17.23	91.79	16.33	92.74
F8	0	0	0	15.89	92.44	16.33	92.74
F9	−1	0	−1	32.21	85.45	31.56	85.53
F10	1	−1	0	78.63	93.56	74.49	93.57
F11	1	0	1	42.18	94.48	42.81	94.4
F12	−1	−1	0	41.23	82.46	39.59	82.03
F13	−1	0	1	13.88	79.33	12.01	79.69
F14	−1	1	0	65.02	81.32	69.16	81.31
F15	0	−1	−1	43.57	89.22	45.84	89.57
F16	0	1	−1	65.79	88.39	62.28	88.32
F17	0	0	0	16.07	93.14	16.33	92.74
Independent variable					Levels
					Low (–1)	Medium (0)	High (1)
A = oil (% v/v)					10	15	20
B = Smix (% v/v)					35	45	55
C = homogenization time (min)					10	15	20
Dependent variables
Y1 = globule size (nm); Y2 = entrapment efficiency (%)