Determination of the Chemical Composition, Antioxidant, and Enzyme Inhibitory Activity of Onosma mollis DC

Table 4

Enzyme inhibition activity of O. mollis extracts.

Enzyme inhibitory activity		EtOAc	MeOH	Water	Galantamine	Kojic acid	Acarbose
AChE inhibition	(IC50: mg/mL)	1.11 ± 0.03^a	1.41 ± 0.04^a	11.54 ± 1.08^b	0.004 ± 0.0003^a	—	—
	(mg GALAEs/g extracts)	2.75 ± 0.06^a	2.16 ± 0.06^b	0.26 ± 0.03^c	—	—	—
BChE inhibition	(IC50: mg/mL)	1.49 ± 0.01^a	6.72 ± 0.26^b	>20.00^c	0.006 ± 0.0001^a	—	—
	(mg GALAEs/g extracts)	3.75 ± 0.04^a	0.83 ± 0.03^b	0.26 ± 0.01^c	—	—	—
Tyrosinase inhibition	(IC50: mg/mL)	3.66 ± 0.01^c	2.94 ± 0.19^b	4.54 ± 0.34^c	—	0.31 ± 0.01^a	—
	(mg KAEs/g extracts)	73.34 ± 0.21^b	91.61 ± 5.98^a	59.26 ± 4.42^c	—	—	—
α-Amylase inhibition	(IC50: mg/mL)	2.63 ± 0.01^b	2.08 ± 0.04^b	16.88 ± 0.30^c	—	—	1.06 ± 0.03^a
	(mgACEs/g extracts)	399.44 ± 2.17^b	504.24 ± 9.45^a	59.80 ± 1.12^c	—	—	—
α-Glucosidase inhibition	(IC50: mg/mL)	1.07 ± 0.01^a	1.55 ± 0.02^b	4.12 ± 0.07^c	—	—	1.65 ± 0.07^b
	(mgACEs/g extracts)	1630.61 ± 10.78^a	1123.62 ± 15.90^b	423.06 ± 7.22^c	—	—	—

GALAEs: galantamine equivalent. KAEs: Kojic acid equivalent. ACEs: Acarbose equivalent. The different superscripts within the same row are different statistically at a 5% significance level.