Isolation, Crystal Structure, and In Silico Aromatase Inhibition Activity of Ergosta-5, 22-dien-3β-ol from the Fungus Gyromitra esculenta

Table 6

Toxicity properties of brassicasterol and the cocrystallized ligand.

Compound	FDA rodent carcinogenicity (rat- male)	Rat maximum tolerated dose (feed)^b	Rat oral LD50^b	Rat chronic LOAEL^b	Ocular irritancy	Skin irritancy
1	Noncarcinogen	0.028	1.071	0.002	Irritant	Moderate
Cocrystallized ligand	Noncarcinogen	0.026	2.015	0.015	Irritant	Moderate

^aUnit: mg/kg body weight/day. ^bUnit: g/kg body weight.