Microwave-Assisted Regioselective Synthesis and 2D-NMR Studies of New 1,2,3-Triazole Compounds Derived from Acridone

Table 1

Optimization of reaction condition 2a.

Entry	Copper salt	Base	Solvent	Time	Yields (%)
1^a	CuI	Et3N	t-BuOH	10 min	52
2^a	CuI	Et3N	DMF	10 min	90
3^a	CuI	Et3N	CHCl3	10 min	62
4^a	CuI	Et3N	MeOH	10 min	38
5^a	CuI	Et3N	DMF	15 min	92
6^b	CuI	Et3N	DMF	10 min	94
7^c	CuI	Et3N	DMF	4 h	62

^aReaction conditions: 10-(prop-2-yn-1-yl)acridone (1 mmol), 2-azidotoluene (2 mmol), copper iodide (0.5 mmol), Et3N (0.6 mmol), and MW 200 W maximum. ^bReaction conditions: 10-(prop-2-yn-1-yl)acridone (1 mmol), 2-azidotoluene (2 mmol), copper iodide (1 mmol), Et3N (1.2 mmol), and MW 200 W maximum. ^cReaction conditions: 10-(prop-2-yn-1-yl)acridone (1 mmol), 2-azidotoluene (2 mmol), copper iodide (1 mmol), and Et3N (1.2 mmol) at 80°C (conventional heating).