Journal of Chemistry / 2021 / Article / Tab 1

Research Article

Chiral Resolution, Absolute Configuration Assignment, and Genotoxicity Evaluation of Racemic 3,4-Dihydroquinazoline as a Novel Anticancer Agent

Table 1

Non-mutagenic effects of racemic (±)-KCP10043F and its two enantiomers in Salmonella typhimurium (TA) and Escherichia coli (E. coli) strains with S9 and without S9a.

StrainRacemate (±)-KCP-10043F(R)-(−)-KCP10043F(S)-(+)-KCP10043F
+S9−S9+S9−S9+S9−S9

Salmonella typhimurium (TA)
 TA98xxxxxx
 TA100xxxxxx
 TA1535xxxxxx
 TA1537xxxxxx
Escherichia coli (E. Coli)
 WP2 uvrA[pKM101]xxxxxx

aThe results were obtained on the baselines by using the calculation of Xenometrix (Xenometric AG, Swiss); After calculating the baseline of DMSO (negative control), the compound was regarded as a mutagen when the induction is more than 2-fold over the baseline and binomial value ≥0.99; x means non-genotoxicity (negative response).

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