Chiral Resolution, Absolute Configuration Assignment, and Genotoxicity Evaluation of Racemic 3,4-Dihydroquinazoline as a Novel Anticancer Agent

Table 1

Non-mutagenic effects of racemic (±)-KCP10043F and its two enantiomers in Salmonella typhimurium (TA) and Escherichia coli (E. coli) strains with S9 and without S9^a.

Strain	Racemate (±)-KCP-10043F		(R)-(−)-KCP10043F		(S)-(+)-KCP10043F
	+S9	−S9	+S9	−S9	+S9	−S9
Salmonella typhimurium (TA)
TA98	x	x	x	x	x	x
TA100	x	x	x	x	x	x
TA1535	x	x	x	x	x	x
TA1537	x	x	x	x	x	x
Escherichia coli (E. Coli)
WP2 uvrA[pKM101]	x	x	x	x	x	x

^aThe results were obtained on the baselines by using the calculation of Xenometrix (Xenometric AG, Swiss); After calculating the baseline of DMSO (negative control), the compound was regarded as a mutagen when the induction is more than 2-fold over the baseline and binomial value ≥0.99; x means non-genotoxicity (negative response).