Journal of Chemistry / 2021 / Article / Tab 2

Research Article

Chiral Resolution, Absolute Configuration Assignment, and Genotoxicity Evaluation of Racemic 3,4-Dihydroquinazoline as a Novel Anticancer Agent

Table 2

Cytotoxicity of racemate (±)-KCP-10043F and its two enantiomers against human cancer cell lines.

CompoundCytotoxicity (IC50: μM)
A549a,bHT-29cPANC-1d

(R)-(−)-KCP10043F9.35 ± 0.295.52 ± 0.4612.96 ± 0.82
(S)-(+)-KCP10043F9.78 ± 0.115.37 ± 0.3110.60 ± 0.13

aHuman lung adenocarcinoma cell line; bIC50 of racemate (±)-KCP-10043F = 7.0 ± 0.1 μM; chuman colorectal adenocarcinoma cell line; dhuman pancreatic cancer cell line.

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