Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity

Table 1

Inhibition rates of compounds 3a–3o against B. d., G. s., V. d., T. c., S. s., and F. o. at 25.0 µg/mL.

Compounds	Inhibition rate (%)
	B. d.	G. s.	V. d.	T. c.	S. s.	F. o.
3a	70.0 ± 1.7	78.7 ± 0.7	67.7 ± 0.9	70.0 ± 1.5	48.0 ± 1.7	25.7 ± 0.5
3b	72.3 ± 1.2	71.8 ± 0.8	79.7 ± 0.6	83.6 ± 1.2	73.9 ± 0.5	76.1 ± 0.5
3c	67.8 ± 1.3	58.5 ± 0.9	46.7 ± 0.6	71.8 ± 0.4	40.3 ± 1.0	63.7 ± 0.6
3d	80.2 ± 1.7	86.1 ± 1.0	81.1 ± 0.6	77.7 ± 0.6	65.8 ± 0.8	12.8 ± 1.7
3e	65.0 ± 1.0	54.4 ± 0.5	51.5 ± 1.5	25.7 ± 0.6	47.2 ± 2.1	0
3f	41.0 ± 1.0	20.4 ± 1.4	41.1 ± 0.5	11.3 ± 0.5	41.2 ± 0.9	0
3g	76.9 ± 1.8	64.8 ± 1.8	34.9 ± 1.6	49.8 ± 1.0	0	19.0 ± 1.0
3h	88.5 ± 1.0	69.9 ± 0.5	68.6 ± 1.6	68.3 ± 0.6	44.0 ± 1.2	6.4 ± 0.9
3i	71.5 ± 0.8	55.3 ± 0.4	56.4 ± 1.0	52.0 ± 1.7	50.0 ± 1.8	42.8 ± 1.3
3j	74.5 ± 0.9	51.6 ± 0.1	66.7 ± 0.7	90.3 ± 0.6	69.1 ± 0.1	50.3 ± 0.9
3k	74.7 ± 1.0	71.3 ± 0.5	56.7 ± 1.0	98.7 ± 0.6	85.5 ± 1.5	55.3 ± 0.1
3l	79.3 ± 0.8	80.5 ± 0.5	80.8 ± 1.0	81.1 ± 0.6	72.7 ± 1.7	0
3m	65.0 ± 1.0	54.4 ± 0.5	51.5 ± 1.5	25.7 ± 0.6	47.2 ± 2.1	0
3n	8.0 ± 1.0	17.3 ± 2.0	44.6 ± 1.6	19.7 ± 1.3	33.8 ± 0.1	0
3o	62.1 ± 1.1	29.7 ± 1.3	16.7 ± 1.4	20.7 ± 1.8	0	32.0 ± 1.0
FP	35.3 ± 0.6	46.9 ± 1.3	21.3 ± 1.2	10.1 ± 1.5	66.1 ± 1.0	25.7 ± 1.0
BS	36.5 ± 1.0	19.8 ± 1.0	82.7 ± 2.3	70.6 ± 1.0	62.8 ± 1.0	13.4 ± 1.4
HM	15.4 ± 1.0	44.6 ± 1.0	30.0 ± 1.0	75.2 ± 0.6	26.9 ± 1.0	50.6 ± 0.5
CB	100	100	33.0 ± 0.5	100	100	100
PC	100	100	75.6 ± 0.5	37.2 ± 1.2	100	100