Journal of Chemistry

Research Article

Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity

Table 2

EC₅₀ values of compounds 3a–3o against tested fungi in vitro.


Comp.	Pathogens	Regression equation	EC₅₀ (µg/mL)	Comp.	Pathogens	Regression equation	EC₅₀ (µg/mL)

3a	B. d.	y = 0.493x + 4.987	1.05 ± 0.17	3h	V. d.	y = 0.541x + 4.696	3.63 ± 0.18
	G. s.	y = 1.104x + 4.220	5.08 ± 0.20	3h	T. c.	y = 1.186x + 3.626	14.4 ± 0.33
	S. s.	y = 1.491x + 3.361	12.6 ± 0.6	3i	B. d.	y = 1.028x + 4.992	1.01 ± 0.09
	T. c.	y = 0.759x + 4.110	14.9 ± 1.3	3j	B. d.	y = 0.562x + 4.483	1.75 ± 0.16
3b	B. d.	y = 0.460x + 4.937	1.36 ± 0.53		S. s.	y = 0.508x + 4.547	7.77 ± 0.70
	G. s.	y = 0.476x + 4.977	1.11 ± 0.13		V. d.	y = 0.672x + 4.543	4.78 ± 0.32
	S. s.	y = 1.545x + 3.651	7.45 ± 0.29		T. c.	y = 1.726x + 4.269	2.64 ± 0.06
	V. d.	y = 0.677x + 4.939	1.22 ± 0.25	3k	B. d.	y = 0.476x + 5.030	0.86 ± 0.12
	T. c.	y = 0.905x + 4.444	4.10 ± 0.27		G. s.	y = 0.596x + 4.772	2.41 ± 0.15
	F. o.	y = 1.162x + 3.984	7.47 ± 0.21		S. s.	y = 1.352x + 3.559	11.6 ± 0.38
3c	B. d.	y = 0.351x + 4.939	1.48 ± 0.22		T. c.	y = 1.578x + 4.636	1.70 ± 0.02
	G. s.	y = 0.281x + 4.806	4.89 ± 0.52	3l	B. d.	y = 0.547x + 5.123	0.59 ± 0.04
	T. c.	y = 0.827x + 4.219	8.77 ± 0.85		G. s.	y = 1.163x + 5.186	0.69 ± 0.04
	F. o.	y = 0.528x + 4.318	19.6 ± 3.5		S. s.	y = 1.352x + 3.559	5.57 ± 0.30
3d	B. d.	y = 0.585x + 4.883	1.58 ± 0.06		V. d.	y = 1.208x + 4.820	1.40 ± 0.06
	G. s.	y = 1.048x + 4.721	1.84 ± 0.12		T. c.	y = 1.150x + 4.330	3.82 ± 0.17
	S. s.	y = 2.100x + 2.913	9.48 ± 0.24	3m	B. d.	y = 0.695x + 4.373	7.97 ± 0.91
	V. d.	y = 1.171x + 4.346	3.61 ± 0.15	3o	B. d.	y = 0.690x + 4.392	7.60 ± 0.51
	T. c.	y = 0.967x + 4.478	3.46 ± 0.23	CB	B. d.	y = 1.131x + 5.996	0.13 ± 0.01
3e	B. d.	y = 0.695x + 4.373	7.97 ± 0.91		G. s.	y = 4.016x + 5.629	0.70 ± 0.01
3f	B. d.	y = 0.507x + 5.015	0.93 ± 0.03		S. s.	y = 3.322x + 7.326	0.20 ± 0.01
3f	G. s.	y = 0.524x + 4.682	4.05 ± 0.12		T. c.	y = 2.322x + 4.772	1.25 ± 0.05
3g	B. d.	y = 0.520x + 5.133	0.55 ± 0.02		F. o.	y = 4.116x + 6.058	0.55 ± 0.01
3g	G. s.	y = 0.558x + 4.815	2.14 ± 0.21