Research Article
Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity
Table 2
EC50 values of compounds 3a–3o against tested fungi in vitro.
| Comp. | Pathogens | Regression equation | EC50 (µg/mL) | Comp. | Pathogens | Regression equation | EC50 (µg/mL) |
| 3a | B. d. | y = 0.493x + 4.987 | 1.05 ± 0.17 | 3h | V. d. | y = 0.541x + 4.696 | 3.63 ± 0.18 | G. s. | y = 1.104x + 4.220 | 5.08 ± 0.20 | T. c. | y = 1.186x + 3.626 | 14.4 ± 0.33 | S. s. | y = 1.491x + 3.361 | 12.6 ± 0.6 | 3i | B. d. | y = 1.028x + 4.992 | 1.01 ± 0.09 | T. c. | y = 0.759x + 4.110 | 14.9 ± 1.3 | 3j | B. d. | y = 0.562x + 4.483 | 1.75 ± 0.16 | 3b | B. d. | y = 0.460x + 4.937 | 1.36 ± 0.53 | S. s. | y = 0.508x + 4.547 | 7.77 ± 0.70 | G. s. | y = 0.476x + 4.977 | 1.11 ± 0.13 | V. d. | y = 0.672x + 4.543 | 4.78 ± 0.32 | S. s. | y = 1.545x + 3.651 | 7.45 ± 0.29 | T. c. | y = 1.726x + 4.269 | 2.64 ± 0.06 | V. d. | y = 0.677x + 4.939 | 1.22 ± 0.25 | 3k | B. d. | y = 0.476x + 5.030 | 0.86 ± 0.12 | T. c. | y = 0.905x + 4.444 | 4.10 ± 0.27 | G. s. | y = 0.596x + 4.772 | 2.41 ± 0.15 | F. o. | y = 1.162x + 3.984 | 7.47 ± 0.21 | S. s. | y = 1.352x + 3.559 | 11.6 ± 0.38 | 3c | B. d. | y = 0.351x + 4.939 | 1.48 ± 0.22 | T. c. | y = 1.578x + 4.636 | 1.70 ± 0.02 | G. s. | y = 0.281x + 4.806 | 4.89 ± 0.52 | 3l | B. d. | y = 0.547x + 5.123 | 0.59 ± 0.04 | T. c. | y = 0.827x + 4.219 | 8.77 ± 0.85 | G. s. | y = 1.163x + 5.186 | 0.69 ± 0.04 | F. o. | y = 0.528x + 4.318 | 19.6 ± 3.5 | S. s. | y = 1.352x + 3.559 | 5.57 ± 0.30 | 3d | B. d. | y = 0.585x + 4.883 | 1.58 ± 0.06 | V. d. | y = 1.208x + 4.820 | 1.40 ± 0.06 | G. s. | y = 1.048x + 4.721 | 1.84 ± 0.12 | T. c. | y = 1.150x + 4.330 | 3.82 ± 0.17 | S. s. | y = 2.100x + 2.913 | 9.48 ± 0.24 | 3m | B. d. | y = 0.695x + 4.373 | 7.97 ± 0.91 | V. d. | y = 1.171x + 4.346 | 3.61 ± 0.15 | 3o | B. d. | y = 0.690x + 4.392 | 7.60 ± 0.51 | T. c. | y = 0.967x + 4.478 | 3.46 ± 0.23 | CB | B. d. | y = 1.131x + 5.996 | 0.13 ± 0.01 | 3e | B. d. | y = 0.695x + 4.373 | 7.97 ± 0.91 | G. s. | y = 4.016x + 5.629 | 0.70 ± 0.01 | 3f | B. d. | y = 0.507x + 5.015 | 0.93 ± 0.03 | S. s. | y = 3.322x + 7.326 | 0.20 ± 0.01 | G. s. | y = 0.524x + 4.682 | 4.05 ± 0.12 | T. c. | y = 2.322x + 4.772 | 1.25 ± 0.05 | 3g | B. d. | y = 0.520x + 5.133 | 0.55 ± 0.02 | F. o. | y = 4.116x + 6.058 | 0.55 ± 0.01 | G. s. | y = 0.558x + 4.815 | 2.14 ± 0.21 | | | | |
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